Clinical and preclinical research indicates that neurodegenerative diseases are
characterized by excess levels of oxidative stress (OS) biomarkers and by lower levels of …

The nuclear factor erythroid 2-related factor 2 (NRF2) was originally described as a master
regulator of antioxidant cellular response, but in the time since, numerous important …

The brain is very sensitive to changes in redox status; thus maintaining redox homeostasis
in the brain is critical for the prevention of accumulating oxidative damage. Aging is the …

NRF2 acts by controlling gene expression, being the master regulator of the Phase II
antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity …

Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

Oxidative stress is a much-appreciated phenomenon associated with the progression of
neurodegenerative diseases (NDDs) due to imbalances in redox homeostasis. The poor …

Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Neurodegenerative diseases share various pathological features, such as accumulation of
aberrant protein aggregates, microglial activation, and mitochondrial dysfunction. These …

Nuclear factor E2–related factor 2 (Nrf2) is a transcription factor known to induce expression
of a variety of cytoprotective and detoxification genes. Several of the genes commonly …

The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the
interface of cellular redox and intermediary metabolism. Nrf2 target genes encode …