In steroid-resistant (SR) asthma, there is a lack of clinical responsiveness to oral prednisone.
Previous studies indicate that this may be explained by the effect of the combination of …

The mechanisms contributing to persistent T cell activation and poor response to
glucocorticoids in chronic inflammatory illnesses such as steroid resistant (SR) asthma are …

We have recently demonstrated that the combination of IL-2 and IL-4 blunts T cell responses
to glucocorticoids in steroid resistant (SR) asthma by reducing glucocorticoid receptor (GCR) …

Interleukin-12 (IL-12) and IL-13 are two recently characterized cytokines which play an
important role in the induction of T helper cell type 1 (Th1-) and Th2-like cells, respectively …

We investigated the phenotype of cells expressing messenger RNA encoding interleukin 4
(IL-4), IL-5, IL-2, and interferon gamma (IFN-gamma) in bronchoalveolar lavage (BAL) and …

We stimulated peripheral blood mononuclear cells from 14 healthy subjects, 14 patients with
stable asthma, and 13 patients with unstable asthma with interleukin (IL)-2 and IL-4 to …

The current study examined whether alterations in glucocorticoid receptor (GR) binding
contribute to poor response to glucocorticoid therapy in asthma. 29 asthma patients with …

We have attempted to identify mRNA for IL-5 in endobronchial mucosal biopsies from
asthmatics and controls, using the technique of in situ hybridization. Bronchial biopsies were …

This study investigated alveolar macrophage function in asthma as assessed by the
presence and source of the cytokine IL-1 beta. Bronchoalveolar lavage (BAL) fluid and cell …

Peripheral blood mononuclear cells (PBMC) and serum were obtained, on two occasions,
from 15 asthmatic patients who required oral glucocorticoid therapy for moderate to severe …