Relationships between the nicotine metabolite ratio and a panel of exposure and effect biomarkers: findings from two studies of US commercial cigarette smokers
DM Carroll, SE Murphy, NL Benowitz, AA Strasser… - … Biomarkers & Prevention, 2020 - AACR
Background: We examined the nicotine metabolite ratio's (NMR) relationship with smoking
intensity, nicotine dependence, and a broad array of biomarkers of exposure and biological …
intensity, nicotine dependence, and a broad array of biomarkers of exposure and biological …
Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers
MJ Chenoweth, M Novalen, LW Hawk Jr… - … Biomarkers & Prevention, 2014 - AACR
Background: The ratio of 3′ hydroxycotinine to cotinine, or nicotine metabolite ratio (NMR),
is strongly associated with CYP2A6 genotype, CYP2A6-mediated nicotine and cotinine …
is strongly associated with CYP2A6 genotype, CYP2A6-mediated nicotine and cotinine …
Nicotine metabolite ratio predicts smoking topography and carcinogen biomarker level
AA Strasser, NL Benowitz, AG Pinto, KZ Tang… - … Biomarkers & Prevention, 2011 - AACR
Background: Variability in smoking behavior is partly attributable to heritable individual
differences in nicotine clearance rates. This can be assessed as the ratio of the metabolites …
differences in nicotine clearance rates. This can be assessed as the ratio of the metabolites …
Associations between nicotine metabolite ratio and gender with transitions in cigarette smoking status and e-cigarette use: findings across waves 1 and 2 of the …
TL Verplaetse, MKR Peltier, W Roberts… - Nicotine and …, 2020 - academic.oup.com
Introduction Nicotine metabolite ratio (NMR), the ratio of trans 3′-hydroxycotinine to
cotinine, is a biomarker of nicotine metabolism. Discrepant findings among clinical trials and …
cotinine, is a biomarker of nicotine metabolism. Discrepant findings among clinical trials and …
The use of the nicotine metabolite ratio as a biomarker to personalize smoking cessation treatment: current evidence and future directions
The nicotine metabolite ratio (NMR), a genetically informed biomarker of rate of nicotine
metabolism, has been validated as a tool to select the optimal treatment for individual …
metabolism, has been validated as a tool to select the optimal treatment for individual …
Reproducibility of the nicotine metabolite ratio in cigarette smokers
G St. Helen, M Novalen, DF Heitjan, D Dempsey… - … , biomarkers & prevention, 2012 - AACR
Background: The nicotine metabolite ratio (NMR or 3-hydroxycotinine/cotinine) has been
used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze …
used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze …
Nicotine metabolite ratios in serum and urine among US adults: variations across smoking status, gender and race/ethnicity
RB Jain - Biomarkers, 2020 - Taylor & Francis
Purpose: The objective of this study was to evaluate factors affecting variabilities in the
observed levels of nicotine metabolite ratios in serum (NMRS, N= 10,234) and urine (NMRU …
observed levels of nicotine metabolite ratios in serum (NMRS, N= 10,234) and urine (NMRU …
Association of reduced nicotine content cigarettes with smoking behaviors and biomarkers of exposure among slow and fast nicotine metabolizers: a nonrandomized …
M Mercincavage, K Lochbuehler, EP Wileyto… - JAMA network …, 2018 - jamanetwork.com
Importance The US Food and Drug Administration (FDA) has announced its intention to
reduce the nicotine content in combustible cigarettes but must base regulation on public …
reduce the nicotine content in combustible cigarettes but must base regulation on public …
A comparison of nicotine biomarkers and smoking patterns in daily and nondaily smokers
S Shiffman, MS Dunbar, NL Benowitz - Cancer epidemiology, biomarkers & …, 2014 - AACR
Background: Nondaily or intermittent smokers (ITS) are increasingly common, but how much
nicotine, if any, ITS take in and how quickly they metabolize it has not yet been studied …
nicotine, if any, ITS take in and how quickly they metabolize it has not yet been studied …
Racial differences in the relationship between rate of nicotine metabolism and nicotine intake from cigarette smoking
KC Ross, NR Gubner, RF Tyndale, LW Hawk Jr… - Pharmacology …, 2016 - Elsevier
Rate of nicotine metabolism has been identified as an important factor influencing nicotine
intake and can be estimated using the nicotine metabolite ratio (NMR), a validated …
intake and can be estimated using the nicotine metabolite ratio (NMR), a validated …