Background: Patients with endoscopy‐negative heartburn can be subdivided into non‐
erosive reflux disease and functional heartburn on the basis of abnormal and normal …

Heartburn is a symptom complex that has traditionally been accepted as an acid-mediated
event and a reliable indicator of gastroesophageal reflux disease. Recently, however, these …

Background Although most patients with gastro‐oesophageal reflux disease (GERD) benefit
from proton pump inhibitor (PPI) therapy, some experience only partial symptom relief. Aim …

Gastroesophageal reflux disease (GERD) is a common disorder in Western countries. For
many years our attention has been focused on patients with erosive esophagitis, but in …

BACKGROUND: The unsatisfactory response to medical treatment in non-erosive patients is
becoming a real challenge for gastroenterologists. Non-responder patients, evaluated under …

Abstract Background/Aims: The diagnostic criteria for nonerosive reflux disease (NERD) and
functional heartburn (FH) have been changed. We investigated demographic, clinical, and …

When patients with the typical reflux symptoms of heartburn, regurgitation, or both, undergo
endoscopy, up to 75% will not have endoscopic oesophagitis or evidence of Barrett's …

Non‐erosive reflux disease (NERD) has emerged as a real entity in the spectrum of
gastroesophageal reflux disease (GERD) and may, indeed, represent the most common …

INTRODUCTION: Functional heartburn is defined by Rome III criteria as an endoscopy-
negative condition with normal oesophageal acid exposure time, negative symptom …

Background Bowel symptoms have been associated with non‐erosive reflux disease
(NERD). However, their role in functional heartburn (FH) has not been established. Aims To …