Anoikis is a specific form of programmed cell death induced by loss of contact between cells
and extracellular matrices or other cells. Only tumor cells that are resistant to anoikis can …

The PTEN tumour suppressor plays critical roles in inhibiting cell proliferation, adhesion and
migration through downregulation of the PI3K-AKT pathway. SIPL1 is a novel PTEN …

The regulation of integrin-mediated cell adhesion and its stabilization involves different
phosphorylation and dephosphorylation events. Focal adhesion kinase (FAK) has been …

As a barrier to metastasis of cancer, cells that lost contact with the neighbouring cells or
extracellular matrix (Extracellular matrix, ECM) will be subjected to apoptosis. This cell death …

Apoptosis‐inducing factor (AIF) exerts dual roles on cell death and survival, but its
substrates as a putative oxidoreductase and roles in tumorigenesis remain elusive. Here, we …

Normal adhering cells undergo apoptosis shortly after loss of adhesion to substratum, a
phenomenon known as" anoikis." In-vitro-transformed cells and cancer-derived cells are …

Normal epithelial cells are anchorage-dependent. Detachment of normal epithelial cells
from their substratum causes apoptosis, termed anoikis. Malignant tumor cells, however, can …

Background The tumor suppressor gene PTEN has been found mutated in many types of
advanced tumors. When introduced into tumor cells that lack the wild-type allele of the gene …

Cell-extracellular matrix adhesive interactions provide a key regulatory mode of cellular
behavior. The molecular basis of adhesion-mediated signaling responses has been under …

PTEN is inactivated in a subset of lung cancer; therefore, we investigated the involvement of
PTEN inactivation in invasiveness of lung cancer cells. AKT at Ser473 was phosphorylated …