Therapeutical relevance of MAP-kinase inhibitors in renal diseases: current knowledge and future clinical perspectives

MT Grande, JM Lopez-Novoa - Current medicinal chemistry, 2008 - ingentaconnect.com
Renal failure, both acute and chronic, represents an important health problem by its social,
sanitary and economic aspects. Mitogen-activated protein kinases (MAPK) are a family of …

Mitogen activated protein kinase signaling in the kidney: target for intervention?

MH de Borst, L Wassef, DJ Kelly… - Signal …, 2006 - Wiley Online Library
Mitogen activated protein kinases (MAPKs) are intracellular signal transduction molecules,
which connect cell‐surface receptor signals to intracellular processes. MAPKs regulate a …

[HTML][HTML] MAP3K kinases and kidney injury

L Cuarental, D Sucunza-Sáenz, L Valiño-Rivas… - Nefrología (English …, 2019 - Elsevier
Mitogen-activated protein kinases (MAP kinases) are functionally connected kinases that
regulate key cellular process involved in kidney disease such as all survival, death …

The role of MAPK in drug‐induced kidney injury

H Cassidy, R Radford, J Slyne… - Journal of signal …, 2012 - Wiley Online Library
This paper focuses on the role that mitogen‐activated protein kinases (MAPKs) play in drug‐
induced kidney injury. The MAPKs, of which there are four major classes (ERK, p38, JNK …

Mitogen-activated protein kinases and hypoxic/ischemic nephropathy

F Luo, J Shi, Q Shi, X Xu, Y Xia, X He - Cellular Physiology and …, 2016 - karger.com
Tissue hypoxia/ischemia is a pathological feature of many human disorders including stroke,
myocardial infarction, hypoxic/ischemic nephropathy, as well as cancer. In the kidney, the …

Inhibition of MAPK Kinase Signaling Pathways Suppressed Renal Cell Carcinoma Growth and Angiogenesis In vivo

D Huang, Y Ding, WM Luo, S Bender, CN Qian, E Kort… - Cancer research, 2008 - AACR
The mitogen-activated protein kinase (MAPK) signaling pathways play essential roles in cell
proliferation and differentiation. Recent studies also show the activation of MAPK signaling …

Differential expression and activation of MAP kinases in dedifferentiated MDCK-focus cells

H Schramek, M Schumacher… - … of Physiology-Cell …, 1997 - journals.physiology.org
Mitogen-activated protein kinases (MAPK) play a key role in the regulation of cellular
processes such as cell growth, cell differentiation, and apoptosis. However, the specific …

Use of inhibitors in the study of MAP kinases

K Burkhard, P Shapiro - MAP Kinase Signaling Protocols: Second Edition, 2010 - Springer
The mitogen-activated protein (MAP) kinases are ubiquitous intracellular signaling proteins
that respond to a variety of extracellular signals and regulate most cellular functions …

JNK, p38, ERK, and SGK1 inhibitors in cancer

J Cicenas, E Zalyte, A Rimkus, D Dapkus, R Noreika… - Cancers, 2017 - mdpi.com
Mitogen-activated protein kinases (MAP kinases) are a family of kinases that regulates a
range of biological processes implicated in the response to growth factors like latelet …

AMP-activated protein kinase as a drug target in chronic kidney disease

S Allouch, S Munusamy - Current Drug Targets, 2018 - ingentaconnect.com
Background: Chronic kidney disease (CKD) is a condition increasingly affecting millions of
individuals worldwide and is ranked as the ninth leading cause of death in the United States …