Necroptosis is a regulated necrotic cell death pathway, mediated by a supermolecular
complex called the necrosome, which contains receptor-interacting protein kinase 1 and 3 …

Upon necroptosis activation, receptor interacting serine/threonine kinase (RIPK) 1 and
RIPK3 form a necrosome complex with pseudokinase mixed lineage kinase-like (MLKL) …

Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death
which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase …

Necroptosis is a caspase-independent, lytic form of programmed cell death whose errant
activation has been widely implicated in many pathologies. The pathway relies on the …

Necroptosis was initially identified as a backup cell death program when apoptosis is
blocked. However, it is now recognized as a cellular defense mechanism against infections …

Cell death has a fundamental impact on the evolution of degenerative disorders,
autoimmune processes, inflammatory diseases, tumor formation and immune surveillance …

Lytic forms of programmed cell death, like necroptosis, are characterised by cell rupture and
the release of cellular contents, often provoking inflammatory responses. In the recent years …

Mixed lineage kinase domain-like pseudokinase (MLKL) mediates necroptosis by
translocating to the plasma membrane and inducing its rupture. The activation of MLKL …

Regulated necrosis, termed necroptosis, is mediated by the kinase activity of RIPK1 and
RIPK3. It has distinct cellular features that are different than apoptosis. Necroptosis can be …

A process of regulated necrosis, termed necroptosis, has been recognized as a major
contributor to cell death and inflammation occurring under a wide range of pathologic …