Atherosclerosis is a complex physiopathologic process initiated by the formation of
cholesterol-rich lesions in the arterial wall. Macrophages play a crucial role in this process …

Conversion of arterial macrophages into foam cells is a key process involved in both the
initiation and progression of atherosclerotic lesions. Foam cell formation involves the …

The development of atherosclerotic plaques in arteries is a key step in atherogenesis, with
cholesterol ester accumulation in macrophage-derived foam cells being recognized as a …

Foam cells formed from receptor-mediated uptake of lipoprotein cholesterol by
macrophages in the arterial intima are critical in the initiation, progression, and stability of …

Cholesterol ester-laden macrophage foam cells are a hallmark of atherosclerosis. The cycle
of esterification and hydrolysis of cholesterol esters is one of the key steps in macrophage …

Unstable lipid-rich plaques in atherosclerosis are characterized by the accumulation of
macrophage foam cells loaded with cholesterol ester (CE). Although hormone-sensitive …

Cholesterol ester (CE)-laden macrophage foam cells are the hallmark of atherosclerosis,
and the hydrolysis of intracellular CE is one of the key steps in foam cell formation. Although …

Cholesteryl ester (CE) accumulation in macrophages represents a crucial event during foam
cell formation, a hallmark of atherogenesis. Here we investigated the role of two previously …

The role of hormone-sensitive lipase (HSL) in the hydrolysis of adipose tissue triacylglycerol
to provide free fatty acids for energy requirements has been well established. However, the …

Reduction of the lipid burden of atherosclerotic lesion-associated macrophage foam cells is
a logical strategy to reduce the plaque volume. Since extracellular cholesterol acceptor …