Abstracts The polysubstituted 4H-pyrano [2, 3-d] pyrimidines 6a-zj containing propargyl
group on nitrogen atom 3 of ring have been synthesized by ring-closing reaction of …

A series of 1H-1, 2, 3-triazole-4H-chromene-D-glucose hybrid compounds 7a-o was
synthesized via click chemistry using 2-amino-7-propargyloxy-4H-chromene-3-carbonitriles …

Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …

A series of pyrazole derivatives (1e–30e) has been designed and synthesized, and their
biological activities were evaluated for EGFR and HER-2 inhibition and tumor cell …

In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …

Abstract The pyrazolo [1, 5-a] pyrimidine core framework is a good starting point for the
synthesis of drug-like molecules since the biological activity is determined by the kind and …

We herein report the design and synthesis of new 1, 3, 5-triazine-based pyrazole derivatives
(5a–i) with anticancer activity targeting the epidermal growth factor (EGFR) tyrosine kinase …

Deregulation of many kinases is directly linked to cancer development and the tyrosine
kinase family is one of the most important targets in current cancer therapy regimens. In this …

A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b)
have been designed and synthesized through the combination of thiazole and pyrazoline …

Currently, the humanity is in a fierce battle against various health-related challenges
especially those associated with human malignancies. This created the urge to develop …