Synthesis and in vitro anticancer activity of 4H-pyrano [2, 3-d] pyrimidine− 1H-1, 2, 3-triazole hybrid compounds bearing D-glucose moiety with dual EGFR/HER2 …
Abstracts The polysubstituted 4H-pyrano [2, 3-d] pyrimidines 6a-zj containing propargyl
group on nitrogen atom 3 of ring have been synthesized by ring-closing reaction of …
group on nitrogen atom 3 of ring have been synthesized by ring-closing reaction of …
Synthesis and antiproliferative activity of 1 H-1, 2, 3-triazole-4 H-chromene-d-glucose hybrid compounds with dual inhibitory activity against EGFR/VEGFR-2 and …
A series of 1H-1, 2, 3-triazole-4H-chromene-D-glucose hybrid compounds 7a-o was
synthesized via click chemistry using 2-amino-7-propargyloxy-4H-chromene-3-carbonitriles …
synthesized via click chemistry using 2-amino-7-propargyloxy-4H-chromene-3-carbonitriles …
Synthesis and biological evaluation of novel [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d] pyrimidines as EGFR targeting anticancer agents
SR Bandi, N Kavitha, SK Nukala… - Journal of Molecular …, 2023 - Elsevier
Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
Synthesis, molecular modeling and biological evaluation of cinnamic acid derivatives with pyrazole moieties as novel anticancer agents
WM Zhang, M Xing, TT Zhao, YJ Ren, XH Yang… - RSC …, 2014 - pubs.rsc.org
A series of pyrazole derivatives (1e–30e) has been designed and synthesized, and their
biological activities were evaluated for EGFR and HER-2 inhibition and tumor cell …
biological activities were evaluated for EGFR and HER-2 inhibition and tumor cell …
Synthesis of novel pyrido [2, 3-d] pyrimidine-thiazolidine-1, 2, 3-triazoles: Potent EGFR targeting anticancer agents
SR Bandi, R Kapavarapu, R Palabindela… - Journal of Molecular …, 2023 - Elsevier
In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …
Synthesis, anticancer activity and molecular docking of new pyrazolo [1, 5-a] pyrimidine derivatives as EGFR/HER2 dual kinase inhibitors
G Sivaiah, R Raveesha, SBB Prasad, KY Kumar… - Journal of Molecular …, 2023 - Elsevier
Abstract The pyrazolo [1, 5-a] pyrimidine core framework is a good starting point for the
synthesis of drug-like molecules since the biological activity is determined by the kind and …
synthesis of drug-like molecules since the biological activity is determined by the kind and …
Novel 1, 3, 5-triazine-based pyrazole derivatives as potential antitumor agents and EFGR kinase inhibitors: Synthesis, cytotoxicity, DNA binding, molecular docking …
We herein report the design and synthesis of new 1, 3, 5-triazine-based pyrazole derivatives
(5a–i) with anticancer activity targeting the epidermal growth factor (EGFR) tyrosine kinase …
(5a–i) with anticancer activity targeting the epidermal growth factor (EGFR) tyrosine kinase …
Design, synthesis and anticancer evaluation of thieno [2, 3-d] pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers
Deregulation of many kinases is directly linked to cancer development and the tyrosine
kinase family is one of the most important targets in current cancer therapy regimens. In this …
kinase family is one of the most important targets in current cancer therapy regimens. In this …
New Thiazolyl-Pyrazoline derivatives as potential dual EGFR/HER2 inhibitors: design, synthesis, anticancer activity evaluation and in silico study
A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b)
have been designed and synthesized through the combination of thiazole and pyrazoline …
have been designed and synthesized through the combination of thiazole and pyrazoline …
Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4, 5-dihydropyrazoles as anticancer agents with …
Currently, the humanity is in a fierce battle against various health-related challenges
especially those associated with human malignancies. This created the urge to develop …
especially those associated with human malignancies. This created the urge to develop …
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