Polymyxin Resistance of Pseudomonas aeruginosa phoQ Mutants Is Dependent on Additional Two-Component Regulatory Systems
AD Gutu, N Sgambati, P Strasbourger… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Pseudomonas aeruginosa can develop resistance to polymyxin as a consequence of
mutations in the PhoPQ regulatory system, mediated by covalent lipid A modification …
mutations in the PhoPQ regulatory system, mediated by covalent lipid A modification …
PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients
AK Miller, MK Brannon, L Stevens… - Antimicrobial agents …, 2011 - Am Soc Microbiol
Pseudomonas aeruginosa can develop resistance to polymyxin and other cationic
antimicrobial peptides. Previous work has shown that mutations in the PmrAB and PhoPQ …
antimicrobial peptides. Previous work has shown that mutations in the PmrAB and PhoPQ …
PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients
SM Moskowitz, MK Brannon, N Dasgupta… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Pseudomonas aeruginosa can develop resistance to polymyxin and other cationic
antimicrobial peptides. Previous work has shown that mutations in the PmrAB and PhoPQ …
antimicrobial peptides. Previous work has shown that mutations in the PmrAB and PhoPQ …
Involvement of pmrAB and phoPQ in Polymyxin B Adaptation and Inducible Resistance in Non-Cystic Fibrosis Clinical Isolates of Pseudomonas aeruginosa
KN Schurek, JLM Sampaio, CRV Kiffer… - Antimicrobial agents …, 2009 - Am Soc Microbiol
During investigation of susceptibility testing methods for polymyxins, 24 multidrug-resistant
clinical isolates of Pseudomonas aeruginosa were observed to have a distinct, reproducible …
clinical isolates of Pseudomonas aeruginosa were observed to have a distinct, reproducible …
[HTML][HTML] Differential role of two-component regulatory systems (phoPQ and pmrAB) in polymyxin B susceptibility of Pseudomonas aeruginosa
D Owusu-Anim, DH Kwon - Advances in microbiology, 2012 - ncbi.nlm.nih.gov
Polymyxins are often considered as a last resort to treat multidrug resistant P. aeruginosa
but polymyxin resistance has been increasingly reported worldwide in clinical isolates …
but polymyxin resistance has been increasingly reported worldwide in clinical isolates …
A single amino acid substitution in PmrB is associated with polymyxin B resistance in clinical isolate of Pseudomonas aeruginosa
N Abraham, DH Kwon - FEMS microbiology letters, 2009 - academic.oup.com
Pseudomonas aeruginosa is a major causative agent of hospital-acquired infections and
infections in cystic fibrosis patients. Treatment of P. aeruginosa is complicated by the …
infections in cystic fibrosis patients. Treatment of P. aeruginosa is complicated by the …
Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa
K Barrow, DH Kwon - Antimicrobial agents and chemotherapy, 2009 - Am Soc Microbiol
Polymyxins are often the only option to treat acquired multidrug-resistant Pseudomonas
aeruginosa. Polymyxin susceptibility in P. aeruginosa PAO1 is associated with the …
aeruginosa. Polymyxin susceptibility in P. aeruginosa PAO1 is associated with the …
Alterations of metabolic and lipid profiles in polymyxin-resistant Pseudomonas aeruginosa
Multidrug-resistant Pseudomonas aeruginosa presents a global medical challenge, and
polymyxins are a key last-resort therapeutic option. Unfortunately, polymyxin resistance in P …
polymyxins are a key last-resort therapeutic option. Unfortunately, polymyxin resistance in P …
A Two-Component Regulatory System Interconnects Resistance to Polymyxins, Aminoglycosides, Fluoroquinolones, and β-Lactams in Pseudomonas aeruginosa
C Muller, P Plésiat, K Jeannot - Antimicrobial agents and …, 2011 - Am Soc Microbiol
Constitutive overexpression of the active efflux system MexXY/OprM is a major cause of
resistance to aminoglycosides, fluoroquinolones, and cefepime in clinical strains of …
resistance to aminoglycosides, fluoroquinolones, and cefepime in clinical strains of …
Characterization of the polymyxin B resistome of Pseudomonas aeruginosa
L Fernández, C Álvarez-Ortega, I Wiegand… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Multidrug resistance in Pseudomonas aeruginosa is increasingly becoming a threat for
human health. Indeed, some strains are resistant to almost all currently available antibiotics …
human health. Indeed, some strains are resistant to almost all currently available antibiotics …