Interneurons, key regulators of hippocampal neuronal network excitability and
synchronization, are lost in advanced stages of Alzheimer's disease (AD). Given that …

Background: It is becoming increasingly recognized that there is significant interneuron
degeneration in Alzheimer's disease. As the hippocampus is integral for learning and …

Alzheimer's disease (AD) is a neurodegenerative disorder that has become a compelling
global public health concern. Besides pathological hallmarks such as extracellular amyloid …

To understand the pathogenesis of specific neuronal circuit dysfunction in Alzheimer's
disease (AD), we investigated the fate of three subclasses of “modulatory interneurons” in …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive
decline and amyloid-beta (Aβ) depositions generated by the proteolysis of amyloid …

Memory loss in Alzheimer's disease (AD) is attributed to pervasive weakening and loss of
synapses. Here, we present findings supporting a special role for excitatory synapses …

Neuronal network dysfunction is increasingly recognized as an early symptom in
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …

Transgenic mice are used to model increased brain amyloid-β (Aβ) and amyloid plaque
formation reflecting Alzheimer's disease pathology. In our study hippocampal network …

Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN)
function as a precipitating factor underlying abnormalities in network synchrony, oscillatory …

At advanced stages, Alzheimer's disease (AD) is characterized by an extensive neuronal
loss. However, the early neurodegenerative deficiencies have not been yet identified. Here …