Abstract Isotretinoin (13-cis-retinoic acid [13CRA], Accutane®) is used for the treatment of
dermatological diseases. Isotretinoin is, however, teratogenic in animals and humans. The …

This paper reviews the teratogenicity of isotretinoin in regard to aspects of species variation,
toxicokinetics, and metabolism. Particular emphasis is given to the hypothesis that most …

13-cis-Retinoic acid (isotretinoin) is teratogenic in man at therapeutic doses (0.5–1.5 mg/kg
body wt), but only marginally teratogenic in the mouse at exceedingly high doses (> 100 …

13-cis-Retinoic acid (isotretinoin) is teratogenic in humans at therapeutic doses (0.5–1.5
mg/kg) but only marginally teratogenic in the mouse at a high dose of 100 mg/kg. Previous …

Previous studies suggested that the rabbit is much more susceptible to the teratogenic
action of 13-cis-retinoic acid (13-cis-RA) than the mouse or the rat, while the teratogenicity of …

The maternal pharmacokinetics, metabolism, and placental transfer of 13-cisretinoic acid
(isotretinoin) have been determined in the cynomolgus monkey using a dosing regimen …

In vitro experiments using whole rat embryo cultures show that all-trans retinoic acid (all-
trans RA) administered at low concentrations (30 ng/ml culture medium) is 10 times more …

All-tra/w-retinoic acid is a potent developmental toxicant in all species examined. The
teratogenic risk of topical all-tranx-retinoic acid is re viewed. Experimental studies are limited …

All-trans-retinoic acid (all-trans-RA) is required in normal embryogenesis and both
deficiency and excess are teratogenic. Isotretinoin (13-cis-RA) is teratogenic in all species …

Maternal administration of 200 mg/kg all‐trans‐retinoic acid to rat embryos at early limb
stages of development (day 12 to day 13.5 post coitum) results in limb reduction defects. In …