The discovery of LOX-1, its ligands and clinical significance
R Yoshimoto, Y Fujita, A Kakino, S Iwamoto… - … drugs and therapy, 2011 - Springer
LOX-1 is an endothelial receptor for oxidized low-density lipoprotein (oxLDL), a key
molecule in the pathogenesis of atherosclerosis. The basal expression of LOX-1 is low but …
molecule in the pathogenesis of atherosclerosis. The basal expression of LOX-1 is low but …
LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis
M Chen, T Masaki, T Sawamura - Pharmacology & therapeutics, 2002 - Elsevier
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) was initially identified
as the major receptor for oxidized LDL (OxLDL) in endothelial cells. Its inducible expression …
as the major receptor for oxidized LDL (OxLDL) in endothelial cells. Its inducible expression …
LOX-1: regulation, signaling and its role in atherosclerosis
Atherosclerosis has long been known to be a chronic inflammatory disease. In addition,
there is intense oxidative stress in atherosclerosis resulting from an imbalance between the …
there is intense oxidative stress in atherosclerosis resulting from an imbalance between the …
Upregulated LOX-1 receptor: key player of the pathogenesis of atherosclerosis
Abstract Purpose of Review In any case, in proatherogenic conditions, LOX-1 is uniquely
upregulated in vascular cells and mediates the entire atherogenic process from LDL …
upregulated in vascular cells and mediates the entire atherogenic process from LDL …
LOX-1 the multifunctional receptor underlying cardiovascular dysfunction
S Ogura, A Kakino, Y Sato, Y Fujita, S Iwamoto… - Circulation …, 2009 - jstage.jst.go.jp
Oxidatively modified low-density lipoprotein (oxLDL) is implicated in the pathogenesis of
atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces …
atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces …
Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders
JL Mehta, J Chen, PL Hermonat, F Romeo… - Cardiovascular …, 2006 - academic.oup.com
Abstract LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …
present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by …
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers
Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …
scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved …
LOX‐1, OxLDL, and atherosclerosis
Oxidized low‐density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation
and progression by several mechanisms, including the induction of endothelial cell …
and progression by several mechanisms, including the induction of endothelial cell …
LOX-1-mediated effects on vascular cells in atherosclerosis
DA Chistiakov, AN Orekhov… - Cellular Physiology and …, 2016 - karger.com
In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-
1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly …
1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly …
LOX-1 in atherosclerosis and myocardial ischemia: biology, genetics, and modulation
NVK Pothineni, SK Karathanasis, Z Ding… - Journal of the American …, 2017 - jacc.org
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), one of the scavenger
receptors for oxidized low-density lipoprotein cholesterol (ox-LDL), plays a crucial role in the …
receptors for oxidized low-density lipoprotein cholesterol (ox-LDL), plays a crucial role in the …