An exposure‐response threshold for lung diseases and lung cancer caused by crystalline silica

LA Cox, Jr - Risk Analysis: An International Journal, 2011 - Wiley Online Library
Whether crystalline silica (CS) exposure increases risk of lung cancer in humans without
silicosis, and, if so, whether the exposure‐response relation has a threshold, have been …

Biological and statistical approaches to predicting human lung cancer risk from silica

ED Kuempel, CL Tran, AJ Bailer… - Journal of …, 2001 - dl.begellhouse.com
Chronic inflammation is a key step in the pathogenesis of particle-elicited fibrosis and lung
cancer in rats, and possibly in humans. In this study, we compute the excess risk estimates …

Silica and lung cancer: a controversial issue

JC Pairon, P Brochard, MC Jaurand… - European Respiratory …, 1991 - Eur Respiratory Soc
The role of crystalline silica in lung cancer has long been the subject of controversy. In this
article, we review the main experimental and epidemiological studies dealing with this …

Crystalline silica and lung cancer: a review of recent experimental evidence

LM Holland - Regulatory toxicology and pharmacology, 1990 - Elsevier
The International Agency for Research in Cancer (IARC) has recently stated that crystalline
silica should be regarded as a potential carcinogen. The IARC bases this statement on a …

Respirable crystalline silica exposure, smoking, and lung cancer subtype risks. A pooled analysis of case–control studies

C Ge, S Peters, A Olsson, L Portengen… - American Journal of …, 2020 - atsjournals.org
Rationale: Millions of workers around the world are exposed to respirable crystalline silica.
Although silica is a confirmed human lung carcinogen, little is known regarding the cancer …

Meta-analysis of studies of lung cancer among silicotics

AH Smith, PA Lopipero, VR Barroga - Epidemiology, 1995 - journals.lww.com
The relation between exposure to crystalline silica and lung cancer has been a controversial
topic, and findings have appeared inconsistent. In this paper, we focus on lung cancer risks …

Silicosis and lung cancer: current perspectives

T Sato, T Shimosato, DM Klinman - Lung Cancer: Targets and …, 2018 - Taylor & Francis
“Silica” refers to crystalline particles formed by the combination of silicon with oxygen.
Inhalation of silica particles promotes the development of pulmonary fibrosis that over …

One agent, many diseases: exposure‐response data and comparative risks of different outcomes following silica exposure

K Steenland - American journal of industrial medicine, 2005 - Wiley Online Library
Background Evidence in recent years indicates that silica causes lung cancer, and probably
renal disease, in addition to its well‐known relationship to silicosis. There is also suggestive …

Crystalline silica and lung cancer: a critical review of the occupational epidemiology literature of exposure-response studies testing this hypothesis

JF Gamble - Critical reviews in toxicology, 2011 - Taylor & Francis
IARC (2009; Metals, Particles and Fibres. IARC Monographs on the Evaluaton of
Carcinogenic Risks to Humans. Volume 100C. Lyon, France: IARC) concluded that …

The effect of silica exposure on the risk of lung cancer: A meta‐analysis

Y Zhou, W Zhang, D Wu, Y Fan - Journal of Biochemical and …, 2023 - Wiley Online Library
Lung cancer is an incurable disease with an increased mortality rate caused by the
inhalation of dust‐containing crystalline silica particles. Silica exposure is one of the most …