Metabolic vulnerabilities of prostate cancer: diagnostic and therapeutic opportunities

G Zadra, M Loda - Cold Spring Harbor …, 2018 - perspectivesinmedicine.cshlp.org
Cancer cells hijack metabolic pathways to support bioenergetics and biosynthetic
requirements for their uncontrolled growth. Thus, cancer can be considered as a metabolic …

Metabolic regulation of prostate cancer heterogeneity and plasticity

C Peitzsch, I Gorodetska, D Klusa, Q Shi… - Seminars in cancer …, 2022 - Elsevier
Metabolic reprogramming is one of the main hallmarks of cancer cells. It refers to the
metabolic adaptations of tumor cells in response to nutrient deficiency, microenvironmental …

Prostate cancer energetics and biosynthesis

C Lin, TC Salzillo, DA Bader, SR Wilkenfeld… - … Cancer: Cellular and …, 2019 - Springer
Cancers must alter their metabolism to satisfy the increased demand for energy and to
produce building blocks that are required to create a rapidly growing tumor. Further, for …

The metabolic landscape of prostate cancer

F Giunchi, M Fiorentino, M Loda - European urology oncology, 2019 - Elsevier
Context Neoplastic cells are characterized by metabolic alterations that sustain tumor
growth. Interventions aimed at modifying metabolic rewiring of cancer cells are currently …

Metabolic phenotyping in prostate cancer using multi-omics approaches

N Gómez-Cebrián, JL Poveda, A Pineda-Lucena… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer (PCa) is a hormone-dependent tumor characterized by a
highly heterogeneous clinical outcome. This neoplastic process has become a leading …

The integration of Metabolomics with other Omics: insights into understanding prostate Cancer

EP Resurreccion, K Fong - Metabolites, 2022 - mdpi.com
Our understanding of prostate cancer (PCa) has shifted from solely caused by a few genetic
aberrations to a combination of complex biochemical dysregulations with the prostate …

Recent advances in metabolic profiling and imaging of prostate cancer

R Thapar, MA Titus - Current Metabolomics, 2014 - ingentaconnect.com
Tumor progression and metastasis are linked to cellular metabolism. Cancer cells, being
highly proliferative, show significant alterations in metabolic pathways such as glycolysis …

Metabolomic profiling of hormone-dependent cancers: a bird's eye view

SM Lloyd, J Arnold, A Sreekumar - Trends in Endocrinology & Metabolism, 2015 - cell.com
Hormone-dependent cancers present a significant public health challenge, because they
are among the most common cancers in the world. One factor associated with cancer …

Metabolic deregulation in prostate cancer

S Srihari, R Kwong, K Tran, R Simpson, P Tattam… - Molecular omics, 2018 - pubs.rsc.org
Introduction: The prostate exhibits a unique metabolism that changes during initial neoplasia
to aggressive prostate cancer (PCa) and metastasis. The study of PCa metabolism thus …

Metabolomic profiling for the identification of novel diagnostic markers and therapeutic targets in prostate cancer: An update

G Lucarelli, D Loizzo, M Ferro… - Expert Review of …, 2019 - Taylor & Francis
Introduction: An altered metabolic regulation is involved in the development and progression
of different cancer types. As well as this, many genes associated with tumors are shown to …