A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development.
D Riethmacher, V Brinkmann… - Proceedings of the …, 1995 - National Acad Sciences
The Ca (2+)-dependent cell adhesion molecule E-cadherin functions in the establishment
and maintenance of epithelial cell morphology during embryogenesis and adulthood …
and maintenance of epithelial cell morphology during embryogenesis and adulthood …
E-cadherin null mutant embryos fail to form a trophectoderm epithelium.
L Larue, M Ohsugi, J Hirchenhain… - Proceedings of the …, 1994 - National Acad Sciences
The cell adhesion molecule E-cadherin mediates the compaction process of mouse
preimplantation embryos and is important for the maintenance and function of epithelial cell …
preimplantation embryos and is important for the maintenance and function of epithelial cell …
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
K Vleminckx, L Vakaet Jr, M Mareel, W Fiers… - Cell, 1991 - cell.com
A cDNA encoding the cell-cell adhesion molecule E-cadherin was transfected tnto highly
invasive epithelial tumor cell lines of dog kidney or mouse mammary gland origin …
invasive epithelial tumor cell lines of dog kidney or mouse mammary gland origin …
Expression of cell adhesion molecule E-cadherin in Xenopus embryos begins at gastrulation and predominates in the ectoderm.
YS Choi, B Gumbiner - The Journal of cell biology, 1989 - rupress.org
The expression of the Ca2+-dependent epithelial cell adhesion molecule E-cadherin (also
known as uvomorulin and L-CAM) in the early stages of embryonic development of Xenopus …
known as uvomorulin and L-CAM) in the early stages of embryonic development of Xenopus …
A role for cadherins in tissue formation
We have produced null mutant mouse embryonic stem cells for the cell adhesion molecule E-
cadherin. Such E-cadherin−/− ES cells are defective in cell aggregation; this defect can be …
cadherin. Such E-cadherin−/− ES cells are defective in cell aggregation; this defect can be …
A functional test for maternally inherited cadherin in Xenopus shows its importance in cell adhesion at the blastula stage
J Heasman, D Ginsberg, B Geiger… - …, 1994 - journals.biologists.com
We report here on the consequences of reducing the expression of EP-cadherin at the
earliest stages of Xenopus development. Injection of oligodeoxynucleotides antisense to …
earliest stages of Xenopus development. Injection of oligodeoxynucleotides antisense to …
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.
UH Frixen, J Behrens, M Sachs, G Eberle… - The Journal of cell …, 1991 - rupress.org
The ability of carcinomas to invade and to metastasize largely depends on the degree of
epithelial differentiation within the tumors, ie, poorly differentiated being more invasive than …
epithelial differentiation within the tumors, ie, poorly differentiated being more invasive than …
Cell-junctional and cytoskeletal organization in mouse blastocysts lacking E-cadherin
M Ohsugi, L Larue, H Schwarz, R Kemler - Developmental biology, 1997 - Elsevier
Trophectoderm epithelium formation, the first visible differentiation process during mouse
embryonic development, is affected in embryos lacking the cell adhesion molecule E …
embryonic development, is affected in embryos lacking the cell adhesion molecule E …
The cell-cell adhesion molecule E-cadherin
F Van Roy, G Berx - Cellular and molecular life sciences, 2008 - Springer
This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …
Molecular cloning and characterization of the human E-cadherin cDNA
MJG Bussemakers, A Van Bokhoven, SGM Mees… - Molecular biology …, 1993 - Springer
E-cadherin is a Ca 2+-dependent cell adhesion molecule involved in cell-cell interaction. In
its normal physiological function it plays an important role in embryonic development and …
its normal physiological function it plays an important role in embryonic development and …