Hypothalamic inflammation and the central nervous system control of energy homeostasis

GD Pimentel, K Ganeshan, JBC Carvalheira - Molecular and cellular …, 2014 - Elsevier
The control of energy homeostasis relies on robust neuronal circuits that regulate food
intake and energy expenditure. Although the physiology of these circuits is well understood …

Contribution of neuroinflammation to the pathogenesis of cancer cachexia

A Molfino, G Gioia, FR Fanelli… - Mediators of …, 2015 - Wiley Online Library
Inflammation characterizes the course of acute and chronic diseases and is largely
responsible for the metabolic and behavioral changes occurring during the clinical journey …

A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding

Y Wang, JM Kim, MB Schmit, TS Cho, C Fang… - Nature …, 2019 - nature.com
Loss of appetite or anorexia associated with inflammation impairs quality of life and
increases morbidity in many diseases. However, the exact neural mechanism that mediates …

Eating disorders: from bench to bedside and back

S Gaetani, A Romano, G Provensi… - Journal of …, 2016 - Wiley Online Library
The central nervous system and viscera constitute a functional ensemble, the gut–brain axis,
that allows bidirectional information flow that contributes to the control of feeding behavior …

Neurobiology of overeating and obesity: the role of melanocortins and beyond

R Pandit, JW de Jong, LJMJ Vanderschuren… - European journal of …, 2011 - Elsevier
The alarming increase in the incidence of obesity and obesity-associated disorders makes
the etiology of obesity a widely studied topic today. As opposed to 'homeostatic feeding' …

Cytokine‐Induced Anorexia: Behavioral, Cellular, and Molecular Mechanismsa

CR PLATA‐SALAMÁN - Annals of the New York Academy of …, 1998 - Wiley Online Library
Cytokines induce anorexia. Recent issues concerning mechanistic aspects are:(1)
Cytokines induce anorexia through different modes of behavioral action, that is, by affecting …

Anorexia in human and experimental animal models: physiological aspects related to neuropeptides

M Yoshimura, Y Uezono, Y Ueta - The journal of physiological sciences, 2015 - Springer
Anorexia, a loss of appetite for food, can be caused by various physiological and
pathophysiological conditions. In this review, firstly, clinical aspects of anorexia nervosa are …

Obesity and neuroinflammation: a pathway to cognitive impairment

AA Miller, SJ Spencer - Brain, behavior, and immunity, 2014 - Elsevier
Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

Neurocircuitry of limbic dysfunction in anorexia nervosa

N Lipsman, DB Woodside, AM Lozano - Cortex, 2015 - Elsevier
Anorexia Nervosa (AN) is a serious psychiatric condition marked by firmly entrenched and
maladaptive behaviors and beliefs about body, weight and food, as well as high rates of …

Lipopolysaccharide inhibits ghrelin-excited neurons of the arcuate nucleus and reduces food intake via central nitric oxide signaling

T Borner, S Pinkernell, TA Lutz, T Riediger - Brain, behavior, and immunity, 2012 - Elsevier
Lipopolysaccharide (LPS) induces anorexia and expression of inducible nitric oxide
synthase (iNOS) in the hypothalamic arcuate nucleus (Arc). Peripheral administration of the …