Therapeutic blockage of cytokine signalling in autoimmune diseases has improved our
understanding of the role of these cytokines in triggering, shaping and perpetuating …

Inflammatory cytokines are key regulators of immune responses. Persistent and excessive
production of inflammatory cytokines underscores the development of autoimmune …

IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. IL-23 is essential
for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic …

Novel cytokine activities are emerging on an ongoing basis. There remain difficulties in
ascribing the optimal regulatory hierarchy for given moieties on the basis of existing …

Rheumatoid arthritis (RA) is well known to be a chronic autoimmune/inflammatory disease
which leads to progressive joint damage and destruction. Less well known is the fact that in …

Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease. It leads to
irreversible joint damage, physical handicap, and reduced life expectancy. The past two …

There is increasing evidence that the IL-6 family of cytokines and signaling pathways
downstream of the common gp130 receptor subunit are important in joint development, in …

Background Until late in the 20th century, the therapy of rheumatic diseases relied on the
use of drugs that had been developed through empirical approaches without detailed …

Psoriasis, an inflammatory skin disease, and psoriatic arthritis (PsA), an inflammatory
arthritis, share clinical, genetic, and pathogenic factors and may be summed as one disease …

Rheumatoid arthritis (RA) is a chronic autoimmune condition of the connective tissue in
synovial joints characterized by inflammation that can lead to impaired movement and …