The discovery of the biological functions of the interleukin-23/-17 axis led to the identification
of IL-23 and IL-17 as important participants in the pathogenesis of several immune-mediated …

Systemic rheumatic diseases are a heterogeneous group of autoimmune disorders that
affect the connective tissue, characterized by the involvement of multiple organs, leading to …

Cytokines affect nearly every biological process; these include embryonic development,
disease pathogenesis, non‐specific response to infection, specific response to antigen …

There have been significant advances in our understanding of human autoimmunity that
have led to improvements in classification and diagnosis and, most importantly, research …

Abstract Treatment of inflammatory arthritides-including rheumatoid arthritis, ankylosing
spondylitis, and psoriatic arthritis-has seen much progress in recent years, partially due to …

Objectives To establish if changes in Th1/Th17 cell populations previously reported in
experimental arthritis occur in patients with rheumatoid arthritis (RA) treated with anti-tumour …

The biology behind interleukin-6 targeted interventions : Current Opinion in Rheumatology The
biology behind interleukin-6 targeted interventions : Current Opinion in Rheumatology Log in or …

Objective Interleukin (IL)-12 and IL-23 have been implicated in the pathogenesis of
rheumatoid arthritis (RA). The safety and efficacy of ustekinumab, a human monoclonal anti …

Rheumatoid arthritis is characterised by pain, swelling, and destruction of joints, with
resultant disability. Only disease-modifying antirheumatic drugs can interfere with the …

Inflammatory arthritis occurs in many diseases and is characterized by joint inflammation
and damage. However, the inflammatory state in arthritis is commonly associated with …