Pharmacologically inhibiting nucleotide-binding domain and leucine-rich repeat-containing
(NLR) family, pyrin domain–containing protein 3 (NLRP3) inflammasome activation results …

The NLRP3 inflammasome plays a crucial role in innate immune-mediated inflammation
and contributes to the pathogenesis of multiple autoinflammatory, metabolic and …

Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

The protein NLRP3 has emerged as a central regulator in the inflammatory process, being
implicated directly in hereditary cryopyrinopathies, and indirectly in diseases such as gout …

Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

Inflammasomes are cytosolic pattern recognition receptors that recognize pathogen-
associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) …

The nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing
3 (NLRP3) responds to a vast variety of stimuli, and activated NLRP3 forms an …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3
(NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in …

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory
form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The …