An in vitro preparation for testing antinociceptive drugs is described. The preparation
consists of isolated spinal cord, spinal nerve roots and functionally connected tail of the …

In the present study, it is proposed that the opioids applied to supraspinal brain sites
produced their analgesic effects by the activation of different descending pain inhibitory …

In man, heterotopic painful thermal conditioning stimuli induce parallel decreases in the
spinal nociceptive flexion (R III) reflex and the concurrent sensation of pain elicited by …

The effect of intrathecal (it) injection of the analgesic agents, codeine, buprenorphine, tilidine
and one of its metabolites, nortilidine, tramadol and nefopam, was determined in the tail-flick …

Lignocaine was tested either alone or in combination with a low dose of morphine by
intrathecal administration on the C-and A-beta evoked responses of nociceptive neurones in …

The effects of sc doses of naloxone, methysergide and phentolamine on ketamine-induced
spinal analgesia were assessed to determine the involvement of opiate, serotonergic and …

The intrathecal administration of thiorphan (dl-3-mercapto-2-benzylpropranoyl-glycine) had
no effect in doses up to 70 μg on the rat hot plate and tail flick. Administration of these doses …

The action of aminophylline on anti-nociceptive effects of morphine in rats was tested on the
tail-flick response to noxious heat and on the activity evoked in ascending axons of the …

The presence of opioid receptors and enkephalin-releasing neurons in the spinal dorsal
horn prompted us to examine whether an enkephalinase inhibitor, SCH32615, given …

Peripheral electrical stimulation of the rat produced a “dose-dependent” analgesia both in
intact and in spinal animals. Naloxone, a narcotic antagonist, almost completely reversed …