Tail-pinch method in vitro and the effects of some antinociceptive compounds
M Yanagisawa, T Murakoshi, S Tamai… - European journal of …, 1984 - Elsevier
An in vitro preparation for testing antinociceptive drugs is described. The preparation
consists of isolated spinal cord, spinal nerve roots and functionally connected tail of the …
consists of isolated spinal cord, spinal nerve roots and functionally connected tail of the …
Differential actions of intrathecal naloxone on blocking the tail-flick inhibition induced by intraventricular beta-endorphin and morphine in rats.
LF Tseng, JM Fujimoto - Journal of Pharmacology and Experimental …, 1985 - ASPET
In the present study, it is proposed that the opioids applied to supraspinal brain sites
produced their analgesic effects by the activation of different descending pain inhibitory …
produced their analgesic effects by the activation of different descending pain inhibitory …
Morphine blocks descending pain inhibitory controls in humans
D Le Bars, JC Willer, T De Broucker - Pain, 1992 - Elsevier
In man, heterotopic painful thermal conditioning stimuli induce parallel decreases in the
spinal nociceptive flexion (R III) reflex and the concurrent sensation of pain elicited by …
spinal nociceptive flexion (R III) reflex and the concurrent sensation of pain elicited by …
Itrathecal injection of codeine, buprenorphine, tildine, tramadol, and nefopam depresses the tail-flick response in rats
G Bernatzky, I Jurna - European journal of pharmacology, 1986 - Elsevier
The effect of intrathecal (it) injection of the analgesic agents, codeine, buprenorphine, tilidine
and one of its metabolites, nortilidine, tramadol and nefopam, was determined in the tail-flick …
and one of its metabolites, nortilidine, tramadol and nefopam, was determined in the tail-flick …
Spinal local anaesthetic actions on afferent evoked responses and wind-up of nociceptive neurones in the rat spinal cord: combination with morphine produces …
HM Fraser, V Chapman, AH Dickenson - Pain, 1992 - Elsevier
Lignocaine was tested either alone or in combination with a low dose of morphine by
intrathecal administration on the C-and A-beta evoked responses of nociceptive neurones in …
intrathecal administration on the C-and A-beta evoked responses of nociceptive neurones in …
The local monoaminergic dependency of spinal ketamine
T Crisp, JM Perrotti, DL Smith, JL Stafinsky… - European journal of …, 1991 - Elsevier
The effects of sc doses of naloxone, methysergide and phentolamine on ketamine-induced
spinal analgesia were assessed to determine the involvement of opiate, serotonergic and …
spinal analgesia were assessed to determine the involvement of opiate, serotonergic and …
Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2, Met5] enkephalin
TL Yaksh, GJ Harty - European Journal of Pharmacology, 1982 - Elsevier
The intrathecal administration of thiorphan (dl-3-mercapto-2-benzylpropranoyl-glycine) had
no effect in doses up to 70 μg on the rat hot plate and tail flick. Administration of these doses …
no effect in doses up to 70 μg on the rat hot plate and tail flick. Administration of these doses …
Aminophylline differentiates between the depressant effects of morphine on the spinal nociceptive reflex and on the spinal ascending activity evoked from afferent C …
I Jurna - European Journal of Pharmacology, 1981 - Elsevier
The action of aminophylline on anti-nociceptive effects of morphine in rats was tested on the
tail-flick response to noxious heat and on the activity evoked in ascending axons of the …
tail-flick response to noxious heat and on the activity evoked in ascending axons of the …
The antinociceptive effects of intrathecally administered SCH32615, an enkephalinase inhibitor in the rat
S Oshita, TL Yaksh, R Chipkin - Brain research, 1990 - Elsevier
The presence of opioid receptors and enkephalin-releasing neurons in the spinal dorsal
horn prompted us to examine whether an enkephalinase inhibitor, SCH32615, given …
horn prompted us to examine whether an enkephalinase inhibitor, SCH32615, given …
Naloxone-reversible peripheral electroanalgesia in intact and spinal rats
CJ Woolf, GD Barrett, D Mitchell, RA Myers - European Journal of …, 1977 - Elsevier
Peripheral electrical stimulation of the rat produced a “dose-dependent” analgesia both in
intact and in spinal animals. Naloxone, a narcotic antagonist, almost completely reversed …
intact and in spinal animals. Naloxone, a narcotic antagonist, almost completely reversed …