The innate immune system recognizes cytosolic DNA associated with microbial infections
and cellular stress via the cGAS/STING pathway, leading to activation of phospho-IRF3 and …

The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …

Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-
stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional …

Background: The cGAS/STING pathway, part of the innate immune response to foreign DNA,
can be activated by cell's own DNA arising from the processing of the genome, including the …

DNA is present in the nucleus and mitochondria of eukaryotic cells. There are, however,
certain instances in which DNA emerges in the cytosol. The two major sources of cytosolic …

Within the cytoplasm of mammalian cells is a protein called cyclic GMP‐AMP synthase
(cGAS), which acts to defend against infection and other threats to the host. cGAS operates …

The major innate immune responder to the DNA of pathogens is the cyclic GMP-AMP
(cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway. Most …

The cGAS/STING signaling pathway is an important part of the cytoplasmic DNA sensor,
which can trigger a type I interferon response to microbial infection when pathogenic DNA is …

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor and innate
immune response initiator. Binding with exogenous or endogenous nucleic acids, cGAS …

Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …