Keratinocyte replicative senescence has an important role in time-dependent changes of the
epidermis, a tissue with high turnover. Senescence encompasses growth arrest during …

We investigated the expression of microRNAs (miRNAs) associated with replicative
senescence in human primary keratinocytes. A cohort of miRNAs up-regulated in …

Aging is a complex process characterized by progressive decline in physiological and
biochemical performance of individual tissues and organs. In aged skin, reduced cell …

The skin protects humans from the surrounding environment. Tissues undergo continuous
renewal throughout an individual's lifetime; however, there is a decline in the regenerative …

The mechanisms affecting epidermal homeostasis during aging remain poorly understood.
To identify age-related microRNAs, a class of non-coding RNAs known to play a key role in …

The aging process starts directly after birth and lasts for the entire lifespan; it manifests itself
with a decline in an organism's ability to adapt and is linked to the development of age …

Ageing of human skin is associated with phenotypic changes in the cutaneous cells; the
major functional markers of ageing occur as consequences of dermal and epidermal cell …

MicroRNAs (miRNAs) are epigenetic regulators of eukaryotic gene expression and play key
roles in many cellular processes. However, the role of miRNAs for replicative senescence of …

Skin senescence is induced by various factors including intrinsic aging and extrinsic aging.
The current study compared the expression of microRNAs in young facial skin and …

Numbers of emerging evidence suggest that variable microRNA (miRNA) expression
facilitates the aging process. In this study, we distinguished aberrant miRNA expression in …