The fundamental message emerging from immunologic and immunopathologic analyses of
the brain and spinal cord in multiple sclerosis (MS) is that during inflammation, the central …

Objective The management of complex patients with neuroimmunological diseases is
hindered by an inability to reliably measure intrathecal inflammation. Currently implemented …

Clonal expansion of B cells and the production of oligoclonal IgG in the brain and
cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) have long been interpreted …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …

The increased intrathecal production of immunoglobulins within the cerebrospinal fluid
(CSF) compartment commonly observed in multiple sclerosis (MS) implicates participation of …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

Multiple sclerosis (MS) is a disabling disease of the CNS. Inflammatory features of MS
include lymphocyte accumulations in the CNS and cerebrospinal fluid (CSF). The preclinical …

Multiple sclerosis (MS) is characterized by demyelinated and inflammatory lesions in the
brain and spinal cord that are highly variable in terms of cellular content. Here, we used …

T cells are considered pivotal in the pathology of multiple sclerosis (MS), but their function
and antigen specificity are unknown. To unravel the role of T cells in MS pathology, we …

While the role of T cells has been studied extensively in multiple sclerosis (MS), the
pathogenic contribution of B cells has only recently attracted major attention, when it was …