No evidence for evolution of protease inhibitor resistance from standard genotyping, after three years of treatment with darunavir/ritonavir, with or without nucleoside …
Editor: In several recent studies, the risk of treatmentemergent drug resistance has been
lower for patients using combinations of two nucleoside analogues plus a boosted protease …
lower for patients using combinations of two nucleoside analogues plus a boosted protease …
Increased resilience to the development of drug resistance with modern boosted protease inhibitor-based highly active antiretroviral therapy
Background. We explore the temporal and regimen-specific changes of HIV-1 drug
resistance in a large cohort of antiretroviral-naive individuals starting highly active …
resistance in a large cohort of antiretroviral-naive individuals starting highly active …
Virological characterization of patients failing darunavir/ritonavir or lopinavir/ritonavir treatment in the ARTEMIS study: 96-week analysis
E Lathouwers, S De Meyer, I Dierynck… - Antiviral …, 2011 - journals.sagepub.com
Background In the Phase III ARTEMIS Trial, treatment-naive patients received once-daily
darunavir/ritonavir (DRV/r) 800/100 mg (n= 343) or lopinavir/ritonavir (LPV/r) 800/200 mg …
darunavir/ritonavir (DRV/r) 800/100 mg (n= 343) or lopinavir/ritonavir (LPV/r) 800/200 mg …
Treatment limitations imposed by antiretroviral drug resistance mutations: implication for choices of first line regimens in resource‐limited settings
Background Recent studies have suggested that failing nonnucleoside reverse transcriptase
inhibitor (NNRTI)‐based regimens may have greater potential to induce the development of …
inhibitor (NNRTI)‐based regimens may have greater potential to induce the development of …
High level of HIV-1 resistance in patients failing long-term first-line antiretroviral therapy in Mali
DB Fofana, C Soulié, A Baldé… - Journal of …, 2014 - academic.oup.com
Objectives In resource-limited settings, few data are available on virological failure after long-
term first-line antiretroviral therapy. This study characterized the genotypic resistance …
term first-line antiretroviral therapy. This study characterized the genotypic resistance …
Drug resistance after failure of initial antiretroviral therapy in resource-limited countries
JE Gallant - Clinical Infectious Diseases, 2007 - academic.oup.com
The report in this issue of Clinical Infectious Diseases by Sungkanuparph et al.[1] from
Thailand provides important confirmation of a long-standing concern regarding failure of …
Thailand provides important confirmation of a long-standing concern regarding failure of …
The cumulative occurrence of resistance mutations in the HIV-1 protease gene is associated with failure of salvage therapy with ritonavir and saquinavir in protease …
M Karmochkine, AS Mohamed, C Piketty, C Ginsburg… - Antiviral research, 2000 - Elsevier
Salvage therapy with ritonavir (RTV) and saquinavir (SQV) failed to achieve virological and
immunological improvement in 24 HIV-infected patients who discontinued triple therapy with …
immunological improvement in 24 HIV-infected patients who discontinued triple therapy with …
Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania
S Henerico, SG Mikasi, SE Kalluvya… - Journal of …, 2022 - academic.oup.com
Background More than 15 million people in sub-Saharan Africa receive ART. Treatment
failure is common, but the role of HIV drug resistance in treatment failure is largely unknown …
failure is common, but the role of HIV drug resistance in treatment failure is largely unknown …
Factors associated with the selection of mutations conferring resistance to protease inhibitors (PIs) in PI-experienced patients displaying treatment failure on darunavir
S Lambert-Niclot, P Flandre, A Canestri… - Antimicrobial agents …, 2008 - Am Soc Microbiol
The objective of this study was to characterize the mutations selected by darunavir (DRV)
use in protease inhibitor (PI)-experienced patients and the associated factors. We analyzed …
use in protease inhibitor (PI)-experienced patients and the associated factors. We analyzed …
Drug resistance testing through remote genotyping and predicted treatment options in human immunodeficiency virus type 1 infected Tanzanian subjects failing first or …
Introduction Antiretroviral therapy (ART) has been successfully introduced in low-middle
income countries. However an increasing rate of ART failure with resistant virus is reported …
income countries. However an increasing rate of ART failure with resistant virus is reported …