Objective The objective of the review is to examine the crossroads of autophagy,
inflammation, and apoptosis signaling pathways and their participation in liver fibrosis …

Liver ischemia/reperfusion injury has been extensively studied during the last decades and
has been implicated in the pathophysiology of many clinical entities following hepatic …

Hepatitis C virus (HCV) is a major cause of viral hepatitis that can progress to hepatic
fibrosis, steatosis, hepatocellular carcinoma, and liver failure. HCV infection is characterized …

Patients with inflammatory liver diseases, particularly alcohol-associated liver disease and
metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of …

The pathogenesis of drug-or toxin-induced liver injury usually involves the participation of
toxic metabolites that either elicit an immune response or directly affect the biochemistry of …

Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic
transplantation, hepatic resection, and trauma. The signaling events contributing to local …

Abstract Ischemia/reperfusion (I/R) injury associated with hepatic resections and liver
transplantation remains a serious complication in clinical practice, despite several attempts …

Simple Summary The liver is continuously exposed to several harmful factors, subsequently
activating sophisticated mechanisms set-up in order to repair and regenerate the damaged …

The unfolded protein response (UPR) is an evolutionarily conserved cell signaling pathway
that is activated to regulate protein synthesis and restore homeostatic equilibrium when the …

Oxidative stress is a host defense mechanism whose involvement in maintaining
homeostasis and/or inducing disease has been widely investigated over the past decade …