Adenosine acts as a cytoprotective modulator in response to stress to an organ or tissue.
Although short-lived in the circulation, it can activate four subtypes of G protein-coupled …

The endogenous neuromodulator adenosine controls and integrates a wide range of brain
functions. Consequently, dysfunction of the adenosine system is involved in pathologies …

This minireview briefly summarizes the evidence that adenosine, acting on four G-protein
coupled receptors, can play physiological roles, but is also critically involved in pathological …

Abstract The A 1, A 2A, A 2B and A 3 G-protein-coupled cell surface adenosine receptors
(ARs) are found to be upregulated in various tumor cells. Activation of the receptors by …

Adenosine accumulation during ischemia and inflammation protects tissues from injury. In
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …

By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular energy …

Adenosine's diverse physiological functions are mediated by four subtypes of receptors (A1,
A2A, A2B and A3). The A1 adenosine receptor pharmacology and therapeutic application of …

Adenosine is a primordial signaling molecule present in every cell of the human body that
mediates its physiological functions by interacting with 4 subtypes of G-protein-coupled …

Adenosine kinase (ADK; EC 2.7. 1.20) is an evolutionarily conserved phosphotransferase
that converts the purine ribonucleoside adenosine into 5′-adenosine-monophosphate …

Background: Adenosine is an endogenous purine nucleoside, which mediates a variety of
important biological processes and diseases, such as vasodilation, inflammation, cancer …