Background: The challenges in developing any A1 adenosine receptor (A1-AdoR) agonist
involve having the desired effect on target tissue while avoiding side effects due to activation …

There are four adenosine receptors, A1, A2A, A2B and A3, together forming a defined
subgroup of G protein coupled receptors. They are well conserved and widely expressed …

The main goal of the authors is to present an overview of adenosine and its receptors, which
are G-protein coupled receptors. The four known adenosine receptor subtypes are …

The A3 adenosine receptor (A3AR) is overexpressed in pathological human cells.
Piclidenoson and namodenoson are A3AR agonists with high affinity and selectivity to …

The regulatory actions of adenosine are mediated via four subtypes of G protein-coupled
receptors distinguished as A 1, A 2A, A 2B and A 3 receptors. Their presence on basically …

Adenosine is a purine nucleoside, responsible for the regulation of a wide range of
physiological and pathophysiological conditions by binding with four G-protein-coupled …

Adenosine is a ubiquitous chemical messenger that modulates cellular activity in both the
CNS and peripheral organs. 1-5 Adenosine levels in the brain extracellular space increase …

Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated
by its interaction with four G-protein-coupled receptor subtypes, termed A1, A2A, A2B and …

Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as
a local regulator in different pathologies. Adenosine is a ubiquitous nucleoside involved in …

Developments in the field of adenosine receptor (AR) agonists of the past years are
presented and discussed. Four different AR subtypes, A1, A2A, A2B, and A3, have been …