The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …

The recent determination of X-ray structures of pharmacologically relevant GPCRs has
made these targets accessible to structure-based ligand discovery. Here we explore …

The adenosine A 1 receptor (A 1-AR) is a G-protein-coupled receptor that plays a vital role in
cardiac, renal, and neuronal processes but remains poorly targeted by current drugs. We …

Inosine is an endogenous purine nucleoside that is produced by catabolism of adenosine.
Adenosine has a short half-life (approximately 10 s) and is rapidly deaminated to inosine, a …

Highlights•Adenosine contributes to tissue integrity by modulating the immune
system.•Adenosine receptor ligands emerged for the management of inflammation.•These …

Extracellular adenosine is produced in a coordinated manner from cells following cellular
challenge or tissue injury. Once produced, it serves as an autocrine-and paracrine-signaling …

Adenosine is a ubiquitous homeostatic substance released from most cells, including
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …

The adenosine A2B receptor is the least well characterized of the four known adenosine
receptor subtypes because of the absence of potent, selective agonists. Here, we present …

The adenosine receptor (AR) subtypes A 2A and A 2B are rhodopsin-like G s protein-
coupled receptors whose expression is highly regulated under pathological, eg hypoxic …

ABSTRACT Introduction: Adenosine A2A Receptor (A2AR) antagonists are an emerging
class of agents that treat cancers, both as a monotherapy and in combination with other …