[HTML][HTML] Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

L Meerstein-Kessel, R van der Lee, W Stone… - Scientific reports, 2018 - nature.com
Plasmodium gametocytes are the sexual forms of the malaria parasite essential for
transmission to mosquitoes. To better understand how gametocytes differ from asexual …

Naturally acquired immunity against immature Plasmodium falciparum gametocytes

KW Dantzler, S Ma, P Ngotho, WJR Stone… - Science translational …, 2019 - science.org
The recent decline in global malaria burden has stimulated efforts toward Plasmodium
falciparum elimination. Understanding the biology of malaria transmission stages may …

[HTML][HTML] The Dynamics of Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs230 & Pfs48/45 in a Low Endemic Area in …

T Bousema, W Roeffen, H Meijerink, H Mwerinde… - PloS one, 2010 - journals.plos.org
Background Naturally acquired immune responses against sexual stages of P. falciparum
can reduce the transmission of malaria from humans to mosquitoes. These antigens are …

The global transcriptome of Plasmodium falciparum mid-stage gametocytes (stages II–IV) appears largely conserved and gametocyte-specific gene expression …

JA Kengne-Ouafo, SY Bah, A Kemp… - Microbiology …, 2023 - Am Soc Microbiol
Our overall understanding of the developmental biology of malaria parasites has been
greatly enhanced by recent advances in transcriptomic analysis. However, most of these …

Naturally acquired immunity to sexual stage P. falciparum parasites

WJR Stone, KW Dantzler, SK Nilsson, CJ Drakeley… - Parasitology, 2016 - cambridge.org
Gametocytes are the specialized form of Plasmodium parasites that are responsible for
human-to-mosquito transmission of malaria. Transmission of gametocytes is highly effective …

[HTML][HTML] Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections

A Barry, J Bradley, W Stone, MW Guelbeogo… - Nature …, 2021 - nature.com
Plasmodium falciparum gametocyte kinetics and infectivity may differ between chronic and
incident infections. In the current study, we assess parasite kinetics and infectivity to …

[HTML][HTML] Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles …

A Roberds, C Kifude, J Oyieko, S Ocholla… - Frontiers in Cellular …, 2022 - frontiersin.org
Despite significant developments towards malaria reduction, parasite transmission in the
common context of HIV-1 co-infection and treatment for one or both infections has not been …

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

RM de Jong, SK Tebeje… - Immunological …, 2020 - Wiley Online Library
The efficient spread of malaria from infected humans to mosquitoes is a major challenge for
malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to …

Recognition of Plasmodium falciparum gametocyte surface antigens by plasma antibodies in asymptomatic Ghanaian school children

B Dinko, T Bousema, CJ Sutherland - Malaria Journal, 2012 - Springer
Background Malaria transmission-reducing interventions are key components of malaria
control and elimination [1]. However, little is known about the immune responses directed at …

[HTML][HTML] The transcriptome of circulating sexually committed Plasmodium falciparum ring stage parasites forecasts malaria transmission potential

SK Prajapati, R Ayanful-Torgby, Z Pava… - Nature …, 2020 - nature.com
Malaria is spread by the transmission of sexual stage parasites, called gametocytes.
However, with Plasmodium falciparum, gametocytes can only be detected in peripheral …