The PTEN conundrum: how to target PTEN-deficient prostate cancer
DJ Turnham, N Bullock, MS Dass, JN Staffurth… - Cells, 2020 - mdpi.com
Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …
[HTML][HTML] Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer
DE Butler, C Marlein, HF Walker, FM Frame, VM Mann… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract The PI3K/AKT/mTOR pathway is frequently activated in advanced prostate cancer,
due to loss of the tumour suppressor PTEN, and is an important axis for drug development …
due to loss of the tumour suppressor PTEN, and is an important axis for drug development …
Targeting drug-resistant prostate cancer with dual PI3K/mTOR inhibition
KD Tang, MT Ling - Current medicinal chemistry, 2014 - ingentaconnect.com
The phosphatidylinositol-3-kinase (PI3K)/Akt/mTOR pathway is one of the most frequently
activated signaling pathways in prostate cancer cells, and loss of the tumor suppressor …
activated signaling pathways in prostate cancer cells, and loss of the tumor suppressor …
Akt down‐modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors
C Festuccia, GL Gravina, P Muzi, D Millimaggi… - The …, 2008 - Wiley Online Library
BACKGROUND PTEN is a well‐characterized tumor suppressor that negatively regulates
cell growth and survival through the modulation of PI3K/Akt pathway. METHODS In this …
cell growth and survival through the modulation of PI3K/Akt pathway. METHODS In this …
PTEN-deficient tumors depend on AKT2 for maintenance and survival
Loss of PTEN is a common event in many cancers and leads to hyperactivation of the PI3K–
AKT signaling pathway. The mechanisms by which AKT isoforms mediate signaling to …
AKT signaling pathway. The mechanisms by which AKT isoforms mediate signaling to …
PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer
DJ Wozniak, A Kajdacsy-Balla, V Macias… - Nature …, 2017 - nature.com
PTEN activity is often lost in prostate cancer. We show that the tyrosine kinase PTK6 (BRK)
is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation …
is a PTEN substrate. Phosphorylation of PTK6 tyrosine 342 (PY342) promotes activation …
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
PK Majumder, PG Febbo, R Bikoff, R Berger, Q Xue… - Nature medicine, 2004 - nature.com
Loss of PTEN function leads to activation of phosphoinositide 3-kinase (PI3K) signaling and
Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition …
Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition …
PI3K/PTEN/AKT pathway: a critical mediator of oncogenic signaling
J Paez, WR Sellers - Signal transduction in cancer, 2004 - Springer
Conclusion In conclusion, direct genetic alterations leading to deregulated PI3K/Akt
signalling are common in a significant fraction of human malignancies. The forthcoming …
signalling are common in a significant fraction of human malignancies. The forthcoming …
Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells
DJ Mulholland, N Kobayashi, M Ruscetti, A Zhi… - Cancer research, 2012 - AACR
Abstract PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate
cancer progression and metastasis. However, in preclinical murine models, deletion of Pten …
cancer progression and metastasis. However, in preclinical murine models, deletion of Pten …