Silica-lipid hybrid (SLH) microcapsules: a novel oral delivery system for poorly soluble drugs
A silica-lipid hybrid (SLH) microcapsule system for oral delivery of poorly water-soluble
drugs is reported for the first time. For the model drug celecoxib (CEL), SLH microcapsules …
drugs is reported for the first time. For the model drug celecoxib (CEL), SLH microcapsules …
Dry hybrid lipid− silica microcapsules engineered from submicron lipid droplets and nanoparticles as a novel delivery system for poorly soluble drugs
We report on the fabrication and characterization of dry hybrid lipid− silica nanoparticle
based microcapsules with an internal porous matrix structure for encapsulation of poorly …
based microcapsules with an internal porous matrix structure for encapsulation of poorly …
Silica–lipid hybrid (SLH) formulations enhance the oral bioavailability and efficacy of celecoxib: An in vivo evaluation
TH Nguyen, A Tan, L Santos, D Ngo… - Journal of controlled …, 2013 - Elsevier
This study is the first to demonstrate in canines the ability of silica-lipid hybrid (SLH)
microparticles to enhance the bioavailability and efficacy of a poorly water-soluble drug after …
microparticles to enhance the bioavailability and efficacy of a poorly water-soluble drug after …
Silica nanoparticles to control the lipase-mediated digestion of lipid-based oral delivery systems
We investigate the role of hydrophilic fumed silica in controlling the digestion kinetics of lipid
emulsions, hence further exploring the mechanisms behind the improved oral absorption of …
emulsions, hence further exploring the mechanisms behind the improved oral absorption of …
Tableting lipid-based formulations for oral drug delivery: a case study with silica nanoparticle–lipid–mannitol hybrid microparticles
KE Bremmell, A Tan, A Martin, CA Prestidge - Journal of Pharmaceutical …, 2013 - Elsevier
Silica–lipid–mannitol hybrid (SLMH) microparticles have been developed that were
compressible into high quality tablets suitable for oral dosing and delivery of poorly soluble …
compressible into high quality tablets suitable for oral dosing and delivery of poorly soluble …
Silica-Lipid Hybrid (SLH) Versus Non-lipid Formulations for Optimising the Dose-Dependent Oral Absorption of Celecoxib
A Tan, AK Davey, CA Prestidge - Pharmaceutical research, 2011 - Springer
Purpose To investigate the dose linearity of celecoxib (CEL) pharmacokinetics from various
non-lipid and lipid-based formulations; to probe the mechanisms of CEL absorption from a …
non-lipid and lipid-based formulations; to probe the mechanisms of CEL absorption from a …
An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles
We report on a porous silica–lipid hybrid microcapsule (SLH) oral delivery system for
indomethacin fabricated from Pickering emulsion templates, where the drug forms an …
indomethacin fabricated from Pickering emulsion templates, where the drug forms an …
Supersaturated silica-lipid hybrids (super-SLH): An improved solid-state lipid-based oral drug delivery system with enhanced drug loading
The method of supersaturation for achieving high drug loads in lipid-based formulations is
under exploited and relatively unexplored, especially in the case of solid-state lipid-based …
under exploited and relatively unexplored, especially in the case of solid-state lipid-based …
Core–shell microcapsules of solid lipid nanoparticles and mesoporous silica for enhanced oral delivery of curcumin
Newly designed microcapsules (MC) combining a core of solid lipid nanoparticle (SLN) and
a mesoporous silica shell have been developed and explored as oral delivery system of …
a mesoporous silica shell have been developed and explored as oral delivery system of …
Silica encapsulated lipid-based drug delivery systems for reducing the fed/fasted variations of ziprasidone in vitro
Ziprasidone is a poorly water-soluble antipsychotic drug that demonstrates low fasted state
oral bioavailability and a clinically significant two-fold increase in absorption when dosed …
oral bioavailability and a clinically significant two-fold increase in absorption when dosed …
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