NF-κB signaling regulates physiological and pathological chondrogenesis
E Jimi, F Huang, C Nakatomi - International journal of molecular sciences, 2019 - mdpi.com
The nuclear factor-κB (NF-κB) is a transcription factor that regulates the expression of genes
that control cell proliferation and apoptosis, as well as genes that respond to inflammation …
that control cell proliferation and apoptosis, as well as genes that respond to inflammation …
[HTML][HTML] NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis
JA Roman-Blas, SA Jimenez - Osteoarthritis and cartilage, 2006 - Elsevier
The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the
regulation of expression of numerous genes in the setting of the inflammatory response …
regulation of expression of numerous genes in the setting of the inflammatory response …
NF-κB signaling pathways in osteoarthritic cartilage destruction
MC Choi, J Jo, J Park, HK Kang, Y Park - Cells, 2019 - mdpi.com
Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …
The NF-κB signalling pathway in osteoarthritis
S Rigoglou, AG Papavassiliou - The international journal of biochemistry & …, 2013 - Elsevier
Nuclear factor-kappaB (NF-κB) proteins constitute a family of transcription factors that are
stimulated by pro-inflammatory cytokines, chemokines, stress-related factors and …
stimulated by pro-inflammatory cytokines, chemokines, stress-related factors and …
NF-κB in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction
SS Makarov - Arthritis Research & Therapy, 2001 - Springer
The transcription factor NF-κB has been well recognized as a pivotal regulator of
inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad …
inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad …
NF-κB as a therapeutic target in inflammatory-associated bone diseases
Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue
homeostasis. In the skeletal system, inflammation is closely associated with many bone …
homeostasis. In the skeletal system, inflammation is closely associated with many bone …
NF-κB signaling in rheumatoid arthritis with focus on fibroblast-like synoviocytes
L Nejatbakhsh Samimi, E Farhadi, MN Tahmasebi… - Autoimmunity …, 2020 - Springer
The nuclear factor-κB (NF-κB) signaling pathway regulates multiple processes in innate and
adaptive immune cells. This pathway is involved in inflammation through the regulation of …
adaptive immune cells. This pathway is involved in inflammation through the regulation of …
Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation
E Olivotto, M Otero, KB Marcu, MB Goldring - RMD open, 2015 - rmdopen.bmj.com
Osteoarthritis (OA), a whole-joint disease driven by abnormal biomechanics and attendant
cell-derived and tissue-derived factors, is a rheumatic disease with the highest prevalence …
cell-derived and tissue-derived factors, is a rheumatic disease with the highest prevalence …
Activation of transcription factor NF‐κB in human synovial cells in response to tumor necrosis factor α
K Fujisawa, H Aono, T Hasunuma… - … : Official Journal of …, 1996 - Wiley Online Library
Objective. To examine whether nuclear factor κB (NF‐κB) is activated in cultured synovial
cells in response to tumor necrosis factor α (TNFα) and to investigate the correlation …
cells in response to tumor necrosis factor α (TNFα) and to investigate the correlation …
NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
AV Miagkov, DV Kovalenko… - Proceedings of the …, 1998 - National Acad Sciences
The transcription factor NF-κB is a pivotal regulator of inflammatory responses. While the
activation of NF-κB in the arthritic joint has been associated with rheumatoid arthritis (RA), its …
activation of NF-κB in the arthritic joint has been associated with rheumatoid arthritis (RA), its …
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