An easy and economical in vitro method for the formation of Candida albicans biofilms under continuous conditions of flow

P Uppuluri, JL Lopez-Ribot - Virulence, 2010 - Taylor & Francis
Candida albicans can develop biofilms on medical devices and these biofilms are most
often nourished by a continuous flow of body fluids and subjected to shear stress forces …

Experimental biofilm-related Candida infections

D Cirasola, R Sciota, L Vizzini, V Ricucci… - Future …, 2013 - Future Medicine
Aim: We investigated the pathogenic role of biofilm and the therapeutic efficacy of
anidulafungin in experimental infections of the wax moth Galleria mellonella by Candida …

Pathogenesis of Candida albicans biofilm

C Tsui, EF Kong, MA Jabra-Rizk - FEMS Pathogens and …, 2016 - academic.oup.com
Candida albicans is the most common human fungal pathogen causing diseases ranging
from mucosal to systemic infections. As a commensal, C. albicans asymptomatically …

Clinical isolates and laboratory reference Candida species and strains have varying abilities to form biofilms

AD Alnuaimi, NM O'Brien-Simpson… - FEMS yeast …, 2013 - academic.oup.com
Candida biofilms are a major virulence trait for this yeast. In this study, the biofilm-forming
ability of the major medically important clinical and laboratory reference strains was …

Candida albicans biofilms: building a heterogeneous, drug-tolerant environment

J Bonhomme, C d'Enfert - Current opinion in microbiology, 2013 - Elsevier
Highlights•We discuss recent advances in understanding fungal biofilm
development.•Fungal biofilm formation is under the control of complex transcriptional …

Screening the Pathogen Box for identification of Candida albicans biofilm inhibitors

T Vila, JL Lopez-Ribot - Antimicrobial Agents and Chemotherapy, 2017 - Am Soc Microbiol
Candida albicans remains the main causative agent of candidiasis, one of the most frequent
nosocomial infections, with unacceptably high mortality rates. Biofilm formation is a major …

Addition of DNase improves the in vitro activity of antifungal drugs against Candida albicans biofilms

M Martins, M Henriques, JL Lopez‐Ribot, R Oliveira - Mycoses, 2012 - Wiley Online Library
Cells within Candida albicans biofilms display decreased susceptibility to most clinically
used antifungal agents. We recently demonstrated that extracellular DNA (eDNA) plays an …

Biofilm Formation by the Fungal PathogenCandida albicans: Development, Architecture, and Drug Resistance

J Chandra, DM Kuhn, PK Mukherjee… - Journal of …, 2001 - Am Soc Microbiol
Biofilms are a protected niche for microorganisms, where they are safe from antibiotic
treatment and can create a source of persistent infection. Using two clinically relevant …

Candida albicans Niche Specialization: Features That Distinguish Biofilm Cells from Commensal Cells

SE Herwald, CA Kumamoto - Current fungal infection reports, 2014 - Springer
The fungus Candida albicans is a frequent commensal colonizer of the human
gastrointestinal (GI) tract, but is also an opportunistic pathogen. This review explores …

Development of a 96-well catheter-based microdilution method to test antifungal susceptibility of Candida biofilms

EI Nweze, A Ghannoum, J Chandra… - Journal of …, 2012 - academic.oup.com
Background Candida biofilms, which are often associated with device-related infections,
including catheter-related bloodstream infections, are resistant to commonly used antifungal …