Activation of metabotropic glutamate receptor 5 (mGluR5) provided neuroprotection in
multiple central nervous system injury, but the roles of mGluR5 in subarachnoid hemorrhage …

A wealth of evidence has shown that microglia-associated neuro-inflammation is involved in
the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI) …

Group I metabotropic glutamate receptors (mGluRs) have been implicated in the
pathophysiology of central nervous system injury, but the role of mGluR5 in traumatic brain …

Traumatic brain injury (TBI) causes microglial activation and related neurotoxicity that
contributes to chronic neurodegeneration and loss of neurological function. Selective …

Excessive glutamate-mediated overactivation of metabotropic glutamate receptor 1
(mGluR1) plays a leading role in neuronal apoptosis following subarachnoid hemorrhage …

We have previously shown that treatment with a mGluR5 positive allosteric modulator (PAM)
is neuroprotective after experimental traumatic brain injury (TBI), limiting post‐traumatic …

Subarachnoid hemorrhage (SAH), as a severe brain disease, has high morbidity and
mortality. SAH usually induced neurological dysfunction or death and the treatment is far …

Previous studies have demonstrated that antagonists of mGluR1, but not mGluR5, are
neuroprotective in models of cerebral ischemia. To investigate the individual roles of mGlu1 …

Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary
tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial …

Several previous studies utilizing selective pharmacological antagonists have demonstrated
that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for …