Invasive mycoses have become an important public health problem as their incidence has
increased dramatically in the last decades, while the discovery of the ideal antifungal agent …

The past decade has seen a significant increase in the incidence of invasive fungal
infections. The antifungal armamentarium for the treatment of serious fungal infections …

In the past decade, we have seen a significant increase in the incidence of invasive fungal
infections. In addition, opportunistic fungal infections resistant to antifungal agents have …

The incidence of invasive fungal infections has been on the rise, particularly in transplant
recipients and in patients with hematological malignancies and other forms of …

During the past two decades the frequencies and types of life-threatening fungal infections
have increased dramatically in immunocompromised patients (7, 220, 232, 282). Several …

The persistence of high morbidity and mortality from systemic fungal infections despite the
availability of novel antifungals points to the need for effective treatment strategies …

We have yet to realize the clinical benefits of combination antifungal therapy, but the
literature is beginning to show the potential positive and negative aspects of this approach …

The use of antifungal combination therapy is a new clinical approach for combating fungal
infections. Although few conclusive clinical studies have been performed to date, data exist …

Recent progress in the therapy of deep-seated mycosis is mostly due to the introduction of
new triazole derivatives for systemic use. However, many problems still remain. The number …

The availability of new antifungal agents with novel mechanisms of action has stimulated
renewed interest in combination antifungal therapies. In particular, and despite the limited …