Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …
Epigenetic modification refers to heritable changes in the genetic material without any …
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …
expression programmes. Significant advances have been made in understanding the …
Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers
D Rong, G Sun, F Wu, Y Cheng, G Sun, W Jiang… - … Therapy-Nucleic Acids, 2021 - cell.com
As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA
modification processes have been reported, and they are widely present in every organism …
modification processes have been reported, and they are widely present in every organism …
Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation
H Shi, P Chai, R Jia, X Fan - Molecular cancer, 2020 - Springer
RNA modifications can be added or removed by a variety of enzymes that catalyse the
necessary reactions, and these modifications play roles in essential molecular mechanisms …
necessary reactions, and these modifications play roles in essential molecular mechanisms …
RNA modifications in cancer: functions, mechanisms, and therapeutic implications
Over 170 chemical modifications have been identified in protein-coding and noncoding
RNAs and shown to exhibit broad impacts on gene expression. Dysregulation of RNA …
RNAs and shown to exhibit broad impacts on gene expression. Dysregulation of RNA …
[HTML][HTML] N1-methyladenosine modification in cancer biology: Current status and future perspectives
J Li, H Zhang, H Wang - Computational and Structural Biotechnology …, 2022 - Elsevier
Post-transcriptional modifications in RNAs regulate their biological behaviors and functions.
N 1-methyladenosine (m 1 A), which is dynamically regulated by writers, erasers and …
N 1-methyladenosine (m 1 A), which is dynamically regulated by writers, erasers and …
RNA methylations in human cancers
RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …
regulating various biological processes, such as RNA transcription, splicing, structure …
Mechanism of RNA modification N6-methyladenosine in human cancer
Z Zhou, J Lv, H Yu, J Han, X Yang, D Feng, Q Wu… - Molecular cancer, 2020 - Springer
Since the breakthrough discoveries of DNA and histone modifications, the field of RNA
modifications has gained increasing interest in the scientific community. The discovery of N6 …
modifications has gained increasing interest in the scientific community. The discovery of N6 …
The RNA Modification N6-Methyladenosine and Its Implications in Human Disease
PJ Batista - Genomics, Proteomics and Bioinformatics, 2017 - academic.oup.com
Impaired gene regulation lies at the heart of many disorders, including developmental
diseases and cancer. Furthermore, the molecular pathways that control gene expression are …
diseases and cancer. Furthermore, the molecular pathways that control gene expression are …
RNA modifications and cancer
ABSTRACT RNA plays essential roles in not only translating nucleic acids into proteins, but
also in gene regulation, environmental interactions and many human diseases. Nature uses …
also in gene regulation, environmental interactions and many human diseases. Nature uses …
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