We analyzed the G-actin-regulated transcriptome by gene expression analysis using
previously characterized actin-binding drugs. We found many known MAL/MRTF-dependent …

Early growth response-1 (Egr-1) is a Cys2-His2-type zinc-finger transcription factor. A broad
range of extracellular stimuli is capable of activating Egr-1, thus mediating growth …

Several genetic studies in Drosophilahave shown that the dSprouty (dSpry) protein inhibits
the Ras/mitogen-activated protein (MAP) kinase pathway induced by various activated …

Mitogen-activated protein kinases (MAPK): Erk1 and Erk2 are key players in negative-
feedback regulation of fibroblast growth factor (FGF) signaling. Upon activation, Erk1 and …

Cell therapy with adult bone marrow multipotential stromal cells/mesenchymal stem cells
(MSCs) presents a promising approach to promote wound healing and tissue regeneration …

The immediate-early gene Egr-1 controls the inducible expression of many genes implicated
in the pathogenesis of a range of vascular disorders, yet our understanding of the …

The early gene early growth response (Egr‐1), a broadly expressed member of the zing‐
finger family of transcription factors, is induced in many cell types by a variety of growth and …

Integrin-mediated activation of small GTPases induces the polymerisation of G-actin into
various actin structures and the release of the transcriptional co-activator MRTF from G-actin …

The precise mechanism whereby epidermal growth factor (EGF) activates the serine-
threonine kinase Akt and the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) …

Monocytes and monocyte-derived macrophages originate through a multistep differentiation
process. First, hematopoietic stem cells generate lineage-restricted progenitors that …