The current study is focused on newly developed phenylpiperazine derivatives of aromatic
methylhydantoin differing in mutual positions of methyl and phenyl moieties. The new …

An analysis of the virtual combinatorial library was used for refining a pilot set of 34
derivatives and designing a targeted 38-member library of the arylamide and …

It has been reported that 5-HT7 receptors are promising targets of depression and
neuropathic pain. 5-HT7 receptor antagonists have exhibited antidepressant-like profiles …

A series of N-(1, 2, 3, 4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides was
prepared and their affinity for serotonin (5-hydroxytryptamine, 5-HT) 5-HT7, 5-HT1A, and 5 …

The well-known 5-HT1A/5-HT7 selectivity issue was tackled by a new series of 4-
aminoethylpiperazinyl aryl ketones (1a–1l) specifically designed to distinguish the two …

HT 7 receptor (5-HT 7 R) agonists and antagonists have been reported to be used for
treatment of neuropathic pain and depression, respectively. In this study, as a novel scaffold …

The present paper concerns the influence of conformational parameters on the recognition
by rat 5-HT1A receptors of derivatives 4-[3-(5-methoxy-1, 2, 3, 4-tetrahydronaphthalen-1-yl) …

A series of novel arylpiperazine 5-(4-fluorophenyl)-5-methylhydantoins with 2-hydroxypropyl
linker (2–15) was synthesized and evaluated on their affinity towards serotonin 5-HT 7 …

Based on our earlier studies of structure activity relationships on 4-substituted piperazine
derivatives, in this work we synthesized a novel set of long-chain arylpiperazines with the …

A focused SAR study around the previously reported selective 5-HT7 receptor antagonist,
SB-269970-A has resulted in the identification of a structurally related analogue having an …