The potency of adrenoceptor and cholinoceptor agents to antagonize the antinociceptive
action of xylazine, an α-sympathomimetic agent, was studied. Yohimbine (1–2 mg/kg) and …

Abstract Xylazine (3–10 mg/kg), clonidine (1–3 mg/kg) and LD 2855, three α-
sympathomimetic agents with marked central effects, were found to be potent …

Xylazine is an α2-adrenoceptor agonist extensively used in veterinary and animal
experimentation. Evidence exists that α2-adrenoceptor agonists can activate opioid …

The effect of drugs that influence the opioidergic and monoaminergic neuronal systems on
the antinociceptive action of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3 …

The intrathecal administration of xylazine (100 micrograms), via a chronic indwelling,
cervical intrathecal catheter, produced a marked elevation of the mechanical nociceptive …

In a first experiment, rats were trained initially to discriminate ip injections of 2.5 mg/kg of
xylazine from saline in a two-lever, food-reinforced, fixed-ratio 10 drug discrimination …

The effects of reducing the activity of norepinephrine in the nervous system, either by
depleting endogenous levels via dopamine-β-hydroxylase inhibition or blocking its effects at …

The present study investigated the effects of WB4101, a selective α 1-adrenoceptor blocking
agent, and idazoxan. a selective α 2-adrenoceptor blocking agent, on antinociception and …

1. In the present work the analgesic effect of benzodiazepines (BZD) and flumazenil (FLU)
using the writhing test in mice was studied. 2. Intracerebroventricular administration of BZD …

The effects of pretreatment with buspirone and its major metabolite 1-(2-pyrimidinyl)-
piperazine (1-PP) on antinociception produced by clonidine were investigated in mice …