3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress
SM Rothman, N Herdener, S Camandola, SJ Texel… - Neurobiology of …, 2012 - Elsevier
Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most
studies of the effects of stress in models of AD utilize acute adverse stressors of …
studies of the effects of stress in models of AD utilize acute adverse stressors of …
Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits
I Sotiropoulos, C Catania, LG Pinto, R Silva… - Journal of …, 2011 - Soc Neuroscience
Stressful life experiences are likely etiological factors in sporadic forms of Alzheimer's
disease (AD). Many AD patients hypersecrete glucocorticoids (GCs), and their GC levels …
disease (AD). Many AD patients hypersecrete glucocorticoids (GCs), and their GC levels …
Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐AD mice
D Baglietto‐Vargas, Y Chen, D Suh… - Journal of …, 2015 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and
other cognitive functions in the elderly. The social and financial impacts of AD are …
other cognitive functions in the elderly. The social and financial impacts of AD are …
Endocrine stress responsivity and social memory in 3xTg-AD female and male mice: A tale of two experiments
ET Nguyen, D Selmanovic, M Maltry, R Morano… - Hormones and …, 2020 - Elsevier
Stress confers risk for the development and progression of Alzheimer's disease (AD).
Relative to men, women are disproportionately more likely to be diagnosed with this …
Relative to men, women are disproportionately more likely to be diagnosed with this …
Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer's disease
TT Tran, M Srivareerat, KA Alkadhi - Neurobiology of disease, 2010 - Elsevier
Although it is generally accepted that Aβ contributes to the pathogenesis of Alzheimer's
disease (AD), other factors that impact the severity and time of onset of the disease are not …
disease (AD), other factors that impact the severity and time of onset of the disease are not …
Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice
M Cuadrado-Tejedor, A Ricobaraza… - Journal of …, 2012 - content.iospress.com
The etiology of the more common (sporadic) forms of Alzheimer's disease (AD) remains
unknown, although age is the most important risk factor. Nevertheless, interactions between …
unknown, although age is the most important risk factor. Nevertheless, interactions between …
Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a …
JC Carroll, M Iba, DA Bangasser… - Journal of …, 2011 - Soc Neuroscience
Because overactivation of the hypothalamic–pituitary–adrenal (HPA) axis occurs in
Alzheimer's disease (AD), dysregulation of stress neuromediators may play a mechanistic …
Alzheimer's disease (AD), dysregulation of stress neuromediators may play a mechanistic …
Chronic social and psychological stress impact select neuropathologies in the PS19 mouse model of tauopathy
CE Lyons, SI Graves, M Razzoli… - Psychosomatic …, 2024 - journals.lww.com
Objective Despite advances toward understanding the etiology of Alzheimer's disease (AD),
it remains unclear which aspects of this disease are affected by environmental factors …
it remains unclear which aspects of this disease are affected by environmental factors …
3xTg-AD mice exhibit an activated central stress axis during early-stage pathology
EK Hebda-Bauer, TA Simmons, A Sugg… - Journal of …, 2013 - content.iospress.com
Activation of the hypothalamic-pituitary-adrenal (HPA) axis occurs in response to the
organism's innate need for homeostasis. The glucocorticoids (GCs) that are released into …
organism's innate need for homeostasis. The glucocorticoids (GCs) that are released into …
Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer's disease model
YH Jeong, CH Park, J Yoo, KY Shin, SM Ahn, HS Kim… - 2006 - s-space.snu.ac.kr
Although chronic stress is known to be linked with memory and other neurological disorders,
little is known about the relationship between chronic stress and the onset or development of …
little is known about the relationship between chronic stress and the onset or development of …