BACKGROUND: Alzheimer's disease (AD) is a degenerative disorder that leads to
progressive cognitive decline. Alzheimer's disease develops as a result of over-production …

Chronic psychosocial stress is increasingly recognized as a risk factor for late-onset
Alzheimer's disease (LOAD) and associated cognitive deficits. Chronic stress also primes …

Neuroendocrine and behavioral stress responses are orchestrated by corticotropin-
releasing hormone (CRH) and norepinephrine (NE) synthesizing neurons. Recent findings …

Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer's
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function …

Systemic inflammation has been implicated in the progression of Alzheimer's disease (AD);
however, less is understood about how existing AD pathology contributes to adverse …

We sought to determine if sex impacts the cognitive and neuropathological phenotype of the
3xTg-AD mice. We find that male and female 3xTg-AD mice show comparable impairments …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder with a complex
physiopathology whose initiators are poorly defined. Accumulating clinical and experimental …

Stress exposure or increased levels of corticotropin-releasing factor (CRF) induce
hippocampal tau phosphorylation (tau-P) in rodent models, a process that is dependent on …

Late-onset Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most
common cause of progressive cognitive dysfunction and dementia. Despite considerable …

Alzheimer's disease (AD) is a progressive, dementing, whole-body disorder that presents
with decline in cognitive, behavioral, and emotional functions, as well as endocrine …