Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

VKM Halagappa, Z Guo, M Pearson, Y Matsuoka… - Neurobiology of …, 2007 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
decline in cognitive function associated with the neuropathological hallmarks amyloid β …

[HTML][HTML] Sex-and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease

L Devi, MJ Alldred, SD Ginsberg, M Ohno - Molecular brain, 2010 - Springer
Background It is hypothesized that complex interactions between multiple environmental
factors and genetic factors are implicated in sporadic Alzheimer's disease (AD); however …

What do we know about the long-term consequences of stress on ageing and the progression of age-related neurodegenerative disorders?

MC Pardon, I Rattray - Neuroscience & Biobehavioral Reviews, 2008 - Elsevier
The aim of this paper is to review evidences that stressful events throughout life can have a
long-term impact on ageing and the progression of Alzheimer's disease. As early as the …

Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice

RA Brachman, ML Lehmann, D Maric… - Journal of …, 2015 - Soc Neuroscience
We examined whether cells of the adaptive immune system retain the memory of
psychosocial stress and thereby alter mood states and CNS function in the host …

Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice

MC Janelsins, MA Mastrangelo, KM Park… - The American journal of …, 2008 - Elsevier
Inflammatory mediators, such as tumor necrosis factor-α (TNF-α) and interleukin-1beta,
appear integral in initiating and/or propagating Alzheimer's disease (AD)-associated …

Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice

A Di Meco, YB Joshi, E Lauretti, D Praticò - Molecular Psychiatry, 2016 - nature.com
Dysregulation of stress hormones, such as glucocorticoids, in adult life increases the risk to
develop Alzheimer's disease (AD). However, the effect of prenatal glucocorticoids exposure …

5xFAD mice display sex-dependent inflammatory gene induction during the prodromal stage of Alzheimer's disease

Z Manji, A Rojas, W Wang… - Journal of …, 2019 - content.iospress.com
Alzheimer's disease (AD) pathology consists of extracellular deposits of amyloid-β peptides
(Aβ) and intracellular neurofibrillary tangles. These pathological alterations are …

Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease

WA Pedersen, C Culmsee, D Ziegler… - Journal of Molecular …, 1999 - Springer
Patients with Alzheimer's disease (AD) exhibit alterations in glucose metabolism and
dysregulation of the stress-responsive hypothalamic-pituitary-adrenal (HPA) …

[HTML][HTML] Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the …

MC Janelsins, MA Mastrangelo, S Oddo… - Journal of …, 2005 - Springer
Background Alzheimer's disease is a complex neurodegenerative disorder characterized
pathologically by a temporal and spatial progression of beta-amyloid (Aβ) deposition …

Restraint stress and repeated corticotrophin-releasing factor receptor activation in the amygdala both increase amyloid-β precursor protein and amyloid-β peptide but …

B Ray, DL Gaskins, TJ Sajdyk, JP Spence, SD Fitz… - Neuroscience, 2011 - Elsevier
Both environmental stress and anxiety may represent important risk factors for Alzheimer's
disease (AD) pathogenesis. Previous studies demonstrate that restraint stress is associated …