Background Ovarian cancer is often diagnosed late leading to poor patient survival. Over
two thirds of women with ovarian cancer are diagnosed with Stages III/IV where the relative …

Epithelial ovarian cancer is the most lethal gynecologic malignancy and has few reliable
non-invasive tests for early detection or diagnosis. Recent advances in genomic techniques …

DNA methylation is a common epigenetic modification, and the current commonly used
methods for DNA methylation detection include methylation-specific PCR, methylation …

Simple Summary There are limited non-invasive methods for detecting epithelial ovarian
cancer despite early detection and treatment dramatically increasing survival. As alterations …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

DNA methylation is an important and reversible epigenetic modification, which regulates
genomic stability and cellular plasticity. Faithful DNA methylation is essential for mammalian …

DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Abstract methyltransferase gene (DNA) methylation is a key process in epigenetic
modification. This transformation leads to genomic instability that creates an impact on gene …

The prognosis of endometrial cancer is strongly associated with stage at diagnosis,
suggesting that early detection may reduce mortality. Women who are diagnosed with …

Background DNA methylation is a stable epigenetic mark that is frequently altered in tumors.
DNA methylation features are attractive biomarkers for disease states given the stability of …