Innate resistance against Mycobacterium tuberculosis is thought to depend critically on
engagement of pattern recognition receptors on macrophages. However, the relative …

Recognition of Mycobacterium tuberculosis by the innate immune system is essential in the
development of an adaptive immune response. Mycobacterial cell wall components activate …

Highlights•TLR2 does not contribute to protection against acute Mtb infection.•TLR2 has a
significant role in protection against chronic Mtb infection.•TLR2 controls immunopathology …

To investigate the role of Toll-like receptor (TLR) 9 in the immune response to mycobacteria
as well as its cooperation with TLR2, a receptor known to be triggered by several major …

Endotoxin from Gram-negative bacteria bound to CD14 signals through Toll-like receptor
(TLR) 4, while components of Gram-positive bacteria, fungi, and Mycobacterium tuberculosis …

The role of Toll‐like receptors (TLR) and MyD88 for immune responses to Mycobacterium
tuberculosis (Mtb) infection remains controversial. To address the impact of TLR‐mediated …

Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis, is an
intracellular bacterium capable of surviving and persisting within host mononuclear cells …

Mycobacterium tuberculosis possesses agonists for several Toll-like receptors (TLRs), yet
mice with single TLR deletions are resistant to acute tuberculosis. MyD88−/− mice were …

Toll‐like receptors (TLR) play an essential role in the innate recognition of microorganisms
by the host. To determine the role of TLR4 in host defense against lung tuberculosis, TLR4 …

This review focuses on recent progress in our understanding of Mycobacterium tuberculosis
survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) …