Caspase-12 is a dominant-negative regulator of caspase-1 (IL-1β-converting enzyme) and
an attenuator of cytokine responsiveness to septic infections. This molecular role for …

The activation of caspase-3 represents a critical step in the pathways leading to the
biochemical and morphological changes that underlie apoptosis. Upon induction of …

Caspases are cysteine proteases that are key effectors in apoptotic cell death. Currently,
there is a lack of tools that can be used to monitor the regulation of specific caspases in the …

Caspase-14 is a developmentally regulated and tissue restricted member of the caspase
family present in mammals. It is mainly found in epidermal keratinocytes and has been …

A unified model for initiator caspase activation has previously been proposed based on the
biochemical analysis of caspase-8 and-9. Caspase-2 is structurally related to caspase-9, but …

Caspase-8 is an apoptotic protease that is activated at the cytosolic face of the cell
membrane. Activation relies on adaptor-induced dimerization of monomeric caspase-8 and …

Members of the caspase family of cysteine proteases coordinate the highly disparate
processes of apoptosis and inflammation. However, although hundreds of substrates for the …

Caspases are central to apoptosis, and the principal executioner caspases, caspase-3 and-
7, were reported to be similar in activity, primary structure, and three-dimensional structure …

Caspase-6 (Casp6) is a short pro-domain caspase that is activated early in Alzheimer
disease, yet, little is known on the mechanism of activation of this caspase. In this study …

A subgroup of caspase family of inflammatory caspases (-1,-4,-5,-11, and-12) play important
role during cytokine maturation and inflammation but their regulation is not well understood …