Cholesterol ester-laden macrophage foam cells are a hallmark of atherosclerosis. The cycle
of esterification and hydrolysis of cholesterol esters is one of the key steps in macrophage …

Cholesterol ester (CE)-laden macrophage foam cells are the hallmark of atherosclerosis,
and the hydrolysis of intracellular CE is one of the key steps in foam cell formation. Although …

Rationale: Hydrolysis of intracellular cholesterol ester (CE) is the key step in the reverse
cholesterol transport in macrophage foam cells. We have recently shown that neutral …

Unstable lipid-rich plaques in atherosclerosis are characterized by the accumulation of
macrophage foam cells loaded with cholesterol ester (CE). Although hormone-sensitive …

Atherosclerosis is a complex physiopathologic process initiated by the formation of
cholesterol-rich lesions in the arterial wall. Macrophages play a crucial role in this process …

Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is
maintained by specialized cells, such as macrophages. Macrophages express a variety of …

Neutral cholesterol ester hydrolase (NCEH) accounts for a large part of the nCEH activity in
macrophage foam cells, a hallmark of atherosclerosis, but its subcellular localization and …

Cholesteryl-ester-loaded macrophages, or foam cells, are prominent features of
atherosclerotic lesions and undoubtedly play important roles in lesion development. Foam …

Conversion of arterial macrophages into foam cells is a key process involved in both the
initiation and progression of atherosclerotic lesions. Foam cell formation involves the …

An excess of cholesterol and/or oxysterols induces apoptosis in macrophages, contributing
to the development of advanced atherosclerotic lesions. In foam cells, these sterols are …