Anti–IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
Y Chen, CL Langrish, B Mckenzie… - The Journal of …, 2006 - Am Soc Clin Investig
IL-23 is a member of the IL-12 cytokine family that drives a highly pathogenic T cell
population involved in the initiation of autoimmune diseases. We have shown that IL-23 …
population involved in the initiation of autoimmune diseases. We have shown that IL-23 …
IL-25 regulates Th17 function in autoimmune inflammation
MA Kleinschek, AM Owyang, B Joyce-Shaikh… - The Journal of …, 2007 - rupress.org
Interleukin (IL)-25 is a member of the IL-17 family of cytokines. However, unlike the other
members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 …
members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 …
A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis
C Sutton, C Brereton, B Keogh, KHG Mills… - The Journal of …, 2006 - rupress.org
It was recently demonstrated that interleukin (IL)-23–driven IL-17–producing (ThIL-17) T
cells mediate inflammatory pathology in certain autoimmune diseases. We show that the …
cells mediate inflammatory pathology in certain autoimmune diseases. We show that the …
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
CL Langrish, Y Chen, WM Blumenschein… - The Journal of …, 2005 - rupress.org
Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a
common p40 subunit shared with IL-12. IL-12 is important for the development of T helper …
common p40 subunit shared with IL-12. IL-12 is important for the development of T helper …
IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production
A Vaknin-Dembinsky, K Balashov… - The Journal of …, 2006 - journals.aai.org
IL-23 is a heterodimeric cytokine comprising a p19 subunit associated with the IL-12/23p40
subunit. Like IL-12, IL-23 is expressed predominantly by activated dendritic cells (DCs) and …
subunit. Like IL-12, IL-23 is expressed predominantly by activated dendritic cells (DCs) and …
Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells
Abstract IL-23, an IL-12 family member, has been implicated in the development of Th17
cells and the progression of autoimmune diseases. However, due to the lack of availability of …
cells and the progression of autoimmune diseases. However, due to the lack of availability of …
Role of the IL-12/IL-23 system in the regulation of T-cell responses in central nervous system inflammatory demyelination
ABSTRACT Interleukin-12 (IL-12) has long been considered essential in T-cell-mediated
autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental …
autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental …
[PDF][PDF] Interleukin-17A serves a priming role in autoimmunity by recruiting IL-1β-producing myeloid cells that promote pathogenic T cells
AM McGinley, CE Sutton, SC Edwards, CM Leane… - Immunity, 2020 - cell.com
Summary Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …
Understanding the IL-23–IL-17 immune pathway
BS McKenzie, RA Kastelein, DJ Cua - Trends in immunology, 2006 - cell.com
Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong
structural relationship that includes a shared p40 subunit, this does not translate into …
structural relationship that includes a shared p40 subunit, this does not translate into …
IL-12-and IL-23 in health and disease
AL Croxford, P Kulig, B Becher - Cytokine & growth factor reviews, 2014 - Elsevier
Abstract Interleukin (IL)-12 and IL-23 play important roles in the development of
experimental autoimmune disease models and numerous afflictions affecting humans …
experimental autoimmune disease models and numerous afflictions affecting humans …