The discovery that the IL-23–IL-17 immune pathway is involved in many models of
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …

The factors that promote the differentiation of pathogenic T cells in autoimmune diseases are
poorly defined. Use of genetically modified mice has provided insight into molecules …

IL-13 is a central mediator of airway hyperresponsiveness and mucus expression, both
hallmarks of asthma. IL-13 is found in the sputum of patients with asthma; therefore, IL-13 is …

The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …

Over the past two decades, our understanding of interleukin-16 (IL-16) has increased
substantially. Initial studies characterizing IL-16 as a chemotactic cytokine (but not a …

It has been suggested that IL-17RC forms a complex with IL-17RA to mediate the functions
of IL-17A and IL-17F homodimers as well as IL-17A/F heterodimers. It is still unclear whether …

IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in
host defence against bacterial and fungal infections, as well as in the pathogenesis of …

Abstract Interleukin 27 (IL-27) was first characterized as a proinflammatory cytokine with T
helper type 1–inducing activity. However, subsequent work has demonstrated that mice …

Summary Although several interleukin-17 (IL-17) family members and their receptors have
been recently appreciated as important regulators in inflammatory diseases, the function of …

Abstract Interleukin 23 (IL-23) is required for autoimmune inflammation mediated by IL-17-
producing helper T cells (TH-17 cells) and has been linked to many human immune …