As one of the key nutrient sensors, insulin signaling plays an important role in integrating
environmental energy cues with organism growth. In adult organisms, relative insufficiency …

Diabetes mellitus represents a major healthcare burden and, due to the increasing
prevalence of type I diabetes and the complications arising from current treatments, other …

Type 1 diabetes is a metabolic disease resulting in the selective loss of pancreatic insulin-
producing β-cells and affecting millions of people worldwide. The side effects of diabetes are …

All pancreatic cell populations arise from the standard gut endoderm layer in developing
embryos, requiring a regulatory gene network to originate and maintain endocrine lineages …

The overall conservation between mouse and human pancreatic development, islet
physiology and etiology of diabetes encourages the translation of novel β cell replacement …

Over the last years, there has been great success in driving stem cells toward insulin-
expressing cells. However, the protocols developed to date have some limitations, such as …

Islet transplantation has proven to be a successful strategy to restore normoglycemia in
patients with type 1 diabetes (T1D). However, the dearth of cadaveric islets available for …

Abstract Knowledge of the pathways involved in islet cell differentiation has been exploited
to develop new methods for generating beta cells from non-beta cells, such as embryonic …

Understanding in detail how pancreatic endocrine cells develop is important for many
reasons. From a scientific point of view, elucidation of such a complex process is a major …

Insulin injections treat but do not cure Type 1 diabetes (T1DM). The success of islet
transplantation suggests cell replacement therapies may offer a curative strategy. However …